Cargando…

Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China

Background: combination vaccines can improve timely vaccination coverage and mitigate the social and economic burdens of both caregivers and health systems. Compared to other countries with high immunization performance, China remains behind the curve in promoting the inclusion of new combination va...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Jiyan, Li, Zhuo, Sun, Yinuo, Liu, Zuokun, Dang, Yuan, Huang, Yangmu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740052/
https://www.ncbi.nlm.nih.gov/pubmed/36497631
http://dx.doi.org/10.3390/ijerph192315557
_version_ 1784847962680066048
author Ma, Jiyan
Li, Zhuo
Sun, Yinuo
Liu, Zuokun
Dang, Yuan
Huang, Yangmu
author_facet Ma, Jiyan
Li, Zhuo
Sun, Yinuo
Liu, Zuokun
Dang, Yuan
Huang, Yangmu
author_sort Ma, Jiyan
collection PubMed
description Background: combination vaccines can improve timely vaccination coverage and mitigate the social and economic burdens of both caregivers and health systems. Compared to other countries with high immunization performance, China remains behind the curve in promoting the inclusion of new combination vaccines into national vaccination schedules. The domestic research and development pipeline faces many technical obstacles, regulatory pressures, and competitive opposition. In addition to this, health disparities regarding combination vaccines exist in each dimension of access and their determinants, including availability, accessibility, acceptability, and quality. Our study aims to provide a cross-disciplinary analysis of China’s combination vaccines (from innovation to access) and identify the main factors that affect the attitudes and behavior choices for combination vaccines. Method: systematic reviews and secondary data analysis will be conducted to map the landscape of combination vaccines in China and the determinants influencing their innovation and access. A cross-sectional survey will be performed in seven provinces of China based on geo-economic representativeness among caregivers with children that are between 2 and 24 months old and are registered in the national immunization system. Questionnaires will be used to examine the relationship between each dimension of access and their determinants. These questionnaires will cover the caregivers’ knowledge, attitude, and willingness to pay for combination vaccines, as well as their perceptions about vaccination services. Semi-structured interviews with the suppliers (public and private) and healthcare providers will help identify research gaps and the key challenges they face when developing and introducing combination vaccines in China. Discussion: using a combined approach, with cross-country and multi-disciplinary support from experts, our research is designed to fill the information gaps in China’s combination vaccine industry across the innovation-access spectrum. It will lead to evidence-based recommendations which will foster greater access to innovation-enhancing combination vaccines for childhood immunization in China. Moreover, the multi-dimensional approach could also be adapted beyond combination vaccines to assess innovation and other public goods for health among disadvantaged groups in the future.
format Online
Article
Text
id pubmed-9740052
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97400522022-12-11 Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China Ma, Jiyan Li, Zhuo Sun, Yinuo Liu, Zuokun Dang, Yuan Huang, Yangmu Int J Environ Res Public Health Protocol Background: combination vaccines can improve timely vaccination coverage and mitigate the social and economic burdens of both caregivers and health systems. Compared to other countries with high immunization performance, China remains behind the curve in promoting the inclusion of new combination vaccines into national vaccination schedules. The domestic research and development pipeline faces many technical obstacles, regulatory pressures, and competitive opposition. In addition to this, health disparities regarding combination vaccines exist in each dimension of access and their determinants, including availability, accessibility, acceptability, and quality. Our study aims to provide a cross-disciplinary analysis of China’s combination vaccines (from innovation to access) and identify the main factors that affect the attitudes and behavior choices for combination vaccines. Method: systematic reviews and secondary data analysis will be conducted to map the landscape of combination vaccines in China and the determinants influencing their innovation and access. A cross-sectional survey will be performed in seven provinces of China based on geo-economic representativeness among caregivers with children that are between 2 and 24 months old and are registered in the national immunization system. Questionnaires will be used to examine the relationship between each dimension of access and their determinants. These questionnaires will cover the caregivers’ knowledge, attitude, and willingness to pay for combination vaccines, as well as their perceptions about vaccination services. Semi-structured interviews with the suppliers (public and private) and healthcare providers will help identify research gaps and the key challenges they face when developing and introducing combination vaccines in China. Discussion: using a combined approach, with cross-country and multi-disciplinary support from experts, our research is designed to fill the information gaps in China’s combination vaccine industry across the innovation-access spectrum. It will lead to evidence-based recommendations which will foster greater access to innovation-enhancing combination vaccines for childhood immunization in China. Moreover, the multi-dimensional approach could also be adapted beyond combination vaccines to assess innovation and other public goods for health among disadvantaged groups in the future. MDPI 2022-11-23 /pmc/articles/PMC9740052/ /pubmed/36497631 http://dx.doi.org/10.3390/ijerph192315557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Ma, Jiyan
Li, Zhuo
Sun, Yinuo
Liu, Zuokun
Dang, Yuan
Huang, Yangmu
Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title_full Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title_fullStr Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title_full_unstemmed Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title_short Improving Innovation and Access to Combination Vaccines for Childhood Immunization in China
title_sort improving innovation and access to combination vaccines for childhood immunization in china
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740052/
https://www.ncbi.nlm.nih.gov/pubmed/36497631
http://dx.doi.org/10.3390/ijerph192315557
work_keys_str_mv AT majiyan improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina
AT lizhuo improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina
AT sunyinuo improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina
AT liuzuokun improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina
AT dangyuan improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina
AT huangyangmu improvinginnovationandaccesstocombinationvaccinesforchildhoodimmunizationinchina