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Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study

Neck circumference (NC) and its relationship to height (NHtR) and weight (NWtR) appear to be good candidates for the non-invasive management of non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the ability of routine variables to assess and manage NAFLD in 98 obese subjects wit...

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Autores principales: Elorz, Mariana, Benito-Boilos, Alberto, Marin, Bertha Araceli, Pérez Díaz del Campo, Nuria, Herrero, Jose Ignacio, Monreal, Jose Ignacio, Tur, Josep A., Martínez, J. Alfredo, Zulet, Maria Angeles, Abete, Itziar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740086/
https://www.ncbi.nlm.nih.gov/pubmed/36501189
http://dx.doi.org/10.3390/nu14235160
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author Elorz, Mariana
Benito-Boilos, Alberto
Marin, Bertha Araceli
Pérez Díaz del Campo, Nuria
Herrero, Jose Ignacio
Monreal, Jose Ignacio
Tur, Josep A.
Martínez, J. Alfredo
Zulet, Maria Angeles
Abete, Itziar
author_facet Elorz, Mariana
Benito-Boilos, Alberto
Marin, Bertha Araceli
Pérez Díaz del Campo, Nuria
Herrero, Jose Ignacio
Monreal, Jose Ignacio
Tur, Josep A.
Martínez, J. Alfredo
Zulet, Maria Angeles
Abete, Itziar
author_sort Elorz, Mariana
collection PubMed
description Neck circumference (NC) and its relationship to height (NHtR) and weight (NWtR) appear to be good candidates for the non-invasive management of non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the ability of routine variables to assess and manage NAFLD in 98 obese subjects with NAFLD included in a 2-year nutritional intervention program. Different measurements were performed at baseline, 6, 12 and 24 months. The nutritional intervention significantly improved the anthropometric, metabolic and imaging variables. NC was significantly associated with the steatosis degree at baseline (r = 0.29), 6 m (r = 0.22), 12 m (r = 0.25), and 24 m (r = 0.39) (all p < 0.05). NC was also significantly associated with visceral adipose tissue at all the study time-points (basal r = 0.78; 6 m r = 0.65; 12 m r = 0.71; 24 m r = 0.77; all p < 0.05). NC and neck ratios combined with ALT levels and HOMA-IR showed a good prediction ability for hepatic fat content and hepatic steatosis (at all time-points) in a ROC analysis. The model improved when weight loss was included in the panel (NC-ROC: 0.982 for steatosis degree). NC and ratios combined with ALT and HOMA-IR showed a good prediction ability for hepatic fat during the intervention. Thus, their application in clinical practice could improve the prevention and management of NAFLD.
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spelling pubmed-97400862022-12-11 Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study Elorz, Mariana Benito-Boilos, Alberto Marin, Bertha Araceli Pérez Díaz del Campo, Nuria Herrero, Jose Ignacio Monreal, Jose Ignacio Tur, Josep A. Martínez, J. Alfredo Zulet, Maria Angeles Abete, Itziar Nutrients Article Neck circumference (NC) and its relationship to height (NHtR) and weight (NWtR) appear to be good candidates for the non-invasive management of non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the ability of routine variables to assess and manage NAFLD in 98 obese subjects with NAFLD included in a 2-year nutritional intervention program. Different measurements were performed at baseline, 6, 12 and 24 months. The nutritional intervention significantly improved the anthropometric, metabolic and imaging variables. NC was significantly associated with the steatosis degree at baseline (r = 0.29), 6 m (r = 0.22), 12 m (r = 0.25), and 24 m (r = 0.39) (all p < 0.05). NC was also significantly associated with visceral adipose tissue at all the study time-points (basal r = 0.78; 6 m r = 0.65; 12 m r = 0.71; 24 m r = 0.77; all p < 0.05). NC and neck ratios combined with ALT levels and HOMA-IR showed a good prediction ability for hepatic fat content and hepatic steatosis (at all time-points) in a ROC analysis. The model improved when weight loss was included in the panel (NC-ROC: 0.982 for steatosis degree). NC and ratios combined with ALT and HOMA-IR showed a good prediction ability for hepatic fat during the intervention. Thus, their application in clinical practice could improve the prevention and management of NAFLD. MDPI 2022-12-04 /pmc/articles/PMC9740086/ /pubmed/36501189 http://dx.doi.org/10.3390/nu14235160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elorz, Mariana
Benito-Boilos, Alberto
Marin, Bertha Araceli
Pérez Díaz del Campo, Nuria
Herrero, Jose Ignacio
Monreal, Jose Ignacio
Tur, Josep A.
Martínez, J. Alfredo
Zulet, Maria Angeles
Abete, Itziar
Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title_full Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title_fullStr Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title_full_unstemmed Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title_short Neck Circumference for NAFLD Assessment during a 2-Year Nutritional Intervention: The FLiO Study
title_sort neck circumference for nafld assessment during a 2-year nutritional intervention: the flio study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740086/
https://www.ncbi.nlm.nih.gov/pubmed/36501189
http://dx.doi.org/10.3390/nu14235160
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