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Role of the Intermediate Filament Protein Peripherin in Health and Disease
Intermediate filaments are the most heterogeneous class among cytoskeletal elements. While some of them have been well-characterized, little is known about peripherin. Peripherin is a class III intermediate filament protein with a specific expression in the peripheral nervous system. Epigenetic modi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740141/ https://www.ncbi.nlm.nih.gov/pubmed/36499746 http://dx.doi.org/10.3390/ijms232315416 |
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author | Romano, Roberta Del Fiore, Victoria Stefania Bucci, Cecilia |
author_facet | Romano, Roberta Del Fiore, Victoria Stefania Bucci, Cecilia |
author_sort | Romano, Roberta |
collection | PubMed |
description | Intermediate filaments are the most heterogeneous class among cytoskeletal elements. While some of them have been well-characterized, little is known about peripherin. Peripherin is a class III intermediate filament protein with a specific expression in the peripheral nervous system. Epigenetic modifications are involved in this cell-type-specific expression. Peripherin has important roles in neurite outgrowth and stability, axonal transport, and axonal myelination. Moreover, peripherin interacts with proteins involved in vesicular trafficking, signal transduction, DNA/RNA processing, protein folding, and mitochondrial metabolism, suggesting a role in all these processes. This review collects information regarding peripherin gene regulation, post-translational modifications, and functions and its involvement in the onset of a number of diseases. |
format | Online Article Text |
id | pubmed-9740141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97401412022-12-11 Role of the Intermediate Filament Protein Peripherin in Health and Disease Romano, Roberta Del Fiore, Victoria Stefania Bucci, Cecilia Int J Mol Sci Review Intermediate filaments are the most heterogeneous class among cytoskeletal elements. While some of them have been well-characterized, little is known about peripherin. Peripherin is a class III intermediate filament protein with a specific expression in the peripheral nervous system. Epigenetic modifications are involved in this cell-type-specific expression. Peripherin has important roles in neurite outgrowth and stability, axonal transport, and axonal myelination. Moreover, peripherin interacts with proteins involved in vesicular trafficking, signal transduction, DNA/RNA processing, protein folding, and mitochondrial metabolism, suggesting a role in all these processes. This review collects information regarding peripherin gene regulation, post-translational modifications, and functions and its involvement in the onset of a number of diseases. MDPI 2022-12-06 /pmc/articles/PMC9740141/ /pubmed/36499746 http://dx.doi.org/10.3390/ijms232315416 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Romano, Roberta Del Fiore, Victoria Stefania Bucci, Cecilia Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title | Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title_full | Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title_fullStr | Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title_full_unstemmed | Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title_short | Role of the Intermediate Filament Protein Peripherin in Health and Disease |
title_sort | role of the intermediate filament protein peripherin in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740141/ https://www.ncbi.nlm.nih.gov/pubmed/36499746 http://dx.doi.org/10.3390/ijms232315416 |
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