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Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2

The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people’s lives...

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Autores principales: Sun, Te-Kai, Huang, Wen-Chin, Sun, Yu-Wen, Deng, Jeng-Shyan, Chien, Liang-Hsuan, Chou, Ya-Ni, Jiang, Wen-Ping, Lin, Jaung-Geng, Huang, Guan-Jhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740160/
https://www.ncbi.nlm.nih.gov/pubmed/36499094
http://dx.doi.org/10.3390/ijms232314766
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author Sun, Te-Kai
Huang, Wen-Chin
Sun, Yu-Wen
Deng, Jeng-Shyan
Chien, Liang-Hsuan
Chou, Ya-Ni
Jiang, Wen-Ping
Lin, Jaung-Geng
Huang, Guan-Jhong
author_facet Sun, Te-Kai
Huang, Wen-Chin
Sun, Yu-Wen
Deng, Jeng-Shyan
Chien, Liang-Hsuan
Chou, Ya-Ni
Jiang, Wen-Ping
Lin, Jaung-Geng
Huang, Guan-Jhong
author_sort Sun, Te-Kai
collection PubMed
description The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people’s lives and economies in the whole world. However, there are still many uncertainties and continued attention to the impact of SARS-CoV-2 on human health. The entry of SARS-CoV-2 into host cells is facilitated by the binding of the spike protein on the virus surface to the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, transmembrane protease serine 2 (TMPRSS2) is a host surface protease that cleaves and proteolytically activates its S protein, which is necessary for viral infection. Thus, SARS-CoV-2 uses the ACE2 receptor for cell entry and initiates the S protein using the protease TMPRSS2. Schizophyllum commune (SC) is one of the most widely distributed fungi, often found on the rotten wood of trees that has been found to have various health benefits, including anticancer, antimicrobial activity, antiparasitic, and immunomodulatory function. In this article, SC significantly diminished the expression ACE2 and TMPRSS2 protein in vitro and in vivo without cell damage. In addition, adenosine from SC was also proven in this experiment to reduce the ACE2 and TMPRSS2 expression. Thus, our findings suggest that SC and adenosine exhibit potential for the repression of SARS-CoV-2 infection via the ACE2 and TMPRSS2 axis.
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spelling pubmed-97401602022-12-11 Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2 Sun, Te-Kai Huang, Wen-Chin Sun, Yu-Wen Deng, Jeng-Shyan Chien, Liang-Hsuan Chou, Ya-Ni Jiang, Wen-Ping Lin, Jaung-Geng Huang, Guan-Jhong Int J Mol Sci Article The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people’s lives and economies in the whole world. However, there are still many uncertainties and continued attention to the impact of SARS-CoV-2 on human health. The entry of SARS-CoV-2 into host cells is facilitated by the binding of the spike protein on the virus surface to the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, transmembrane protease serine 2 (TMPRSS2) is a host surface protease that cleaves and proteolytically activates its S protein, which is necessary for viral infection. Thus, SARS-CoV-2 uses the ACE2 receptor for cell entry and initiates the S protein using the protease TMPRSS2. Schizophyllum commune (SC) is one of the most widely distributed fungi, often found on the rotten wood of trees that has been found to have various health benefits, including anticancer, antimicrobial activity, antiparasitic, and immunomodulatory function. In this article, SC significantly diminished the expression ACE2 and TMPRSS2 protein in vitro and in vivo without cell damage. In addition, adenosine from SC was also proven in this experiment to reduce the ACE2 and TMPRSS2 expression. Thus, our findings suggest that SC and adenosine exhibit potential for the repression of SARS-CoV-2 infection via the ACE2 and TMPRSS2 axis. MDPI 2022-11-25 /pmc/articles/PMC9740160/ /pubmed/36499094 http://dx.doi.org/10.3390/ijms232314766 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Te-Kai
Huang, Wen-Chin
Sun, Yu-Wen
Deng, Jeng-Shyan
Chien, Liang-Hsuan
Chou, Ya-Ni
Jiang, Wen-Ping
Lin, Jaung-Geng
Huang, Guan-Jhong
Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title_full Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title_fullStr Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title_full_unstemmed Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title_short Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
title_sort schizophyllum commune reduces expression of the sars-cov-2 receptors ace2 and tmprss2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740160/
https://www.ncbi.nlm.nih.gov/pubmed/36499094
http://dx.doi.org/10.3390/ijms232314766
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