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Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study

This study evaluated the mid-term (12-month) biomechanical, biocompatibility, and biological performance of additive-manufactured bioabsorbable iron-based interference screws (ISs). Two bioabsorbable iron IS types—manufactured using pure iron powder (iron_IS) and using pure iron powder with 0.2 wt%...

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Autores principales: Tai, Chien-Cheng, Huang, Yu-Min, Liaw, Chen-Kun, Yang, Kuo-Yi, Ma, Chun-Hsien, Huang, Shin-I, Huang, Chih-Chieh, Tsai, Pei-I, Shen, Hsin-Hsin, Sun, Jui-Sheng, Chen, Chih-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740248/
https://www.ncbi.nlm.nih.gov/pubmed/36498952
http://dx.doi.org/10.3390/ijms232314626
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author Tai, Chien-Cheng
Huang, Yu-Min
Liaw, Chen-Kun
Yang, Kuo-Yi
Ma, Chun-Hsien
Huang, Shin-I
Huang, Chih-Chieh
Tsai, Pei-I
Shen, Hsin-Hsin
Sun, Jui-Sheng
Chen, Chih-Yu
author_facet Tai, Chien-Cheng
Huang, Yu-Min
Liaw, Chen-Kun
Yang, Kuo-Yi
Ma, Chun-Hsien
Huang, Shin-I
Huang, Chih-Chieh
Tsai, Pei-I
Shen, Hsin-Hsin
Sun, Jui-Sheng
Chen, Chih-Yu
author_sort Tai, Chien-Cheng
collection PubMed
description This study evaluated the mid-term (12-month) biomechanical, biocompatibility, and biological performance of additive-manufactured bioabsorbable iron-based interference screws (ISs). Two bioabsorbable iron IS types—manufactured using pure iron powder (iron_IS) and using pure iron powder with 0.2 wt% tricalcium phosphate (TCP_IS)—were compared with conventional metallic IS (control) using in vitro biocompatibility and degradation analyses and an in vivo animal study. The in vitro ultimate failure strength was significantly higher for iron_IS and TCP_IS than for control ISs at 3 months post-operatively; however, the difference between groups were nonsignificant thereafter. Moreover, at 3 months after implantation, iron_IS and TCP_IS increased bone volume fraction, bone surface area fraction, and percent intersection surface; the changes thereafter were nonsignificant. Iron_IS and TCP_IS demonstrated degradation over time with increased implant surface, decreased implant volume, and structure thickness; nevertheless, the analyses of visceral organs and biochemistry demonstrated normal results, except for time-dependent iron deposition in the spleen. Therefore, compared with conventional ISs, bioabsorbable iron-based ISs exhibit higher initial mechanical strength. Although iron-based ISs demonstrate high biocompatibility 12 months after implantation, their corrosive iron products may accumulate in the spleen. Because they demonstrate mechanical superiority along with considerable absorption capability after implantation, iron-based ISs may have potential applications in implantable medical-device development in the future.
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spelling pubmed-97402482022-12-11 Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study Tai, Chien-Cheng Huang, Yu-Min Liaw, Chen-Kun Yang, Kuo-Yi Ma, Chun-Hsien Huang, Shin-I Huang, Chih-Chieh Tsai, Pei-I Shen, Hsin-Hsin Sun, Jui-Sheng Chen, Chih-Yu Int J Mol Sci Article This study evaluated the mid-term (12-month) biomechanical, biocompatibility, and biological performance of additive-manufactured bioabsorbable iron-based interference screws (ISs). Two bioabsorbable iron IS types—manufactured using pure iron powder (iron_IS) and using pure iron powder with 0.2 wt% tricalcium phosphate (TCP_IS)—were compared with conventional metallic IS (control) using in vitro biocompatibility and degradation analyses and an in vivo animal study. The in vitro ultimate failure strength was significantly higher for iron_IS and TCP_IS than for control ISs at 3 months post-operatively; however, the difference between groups were nonsignificant thereafter. Moreover, at 3 months after implantation, iron_IS and TCP_IS increased bone volume fraction, bone surface area fraction, and percent intersection surface; the changes thereafter were nonsignificant. Iron_IS and TCP_IS demonstrated degradation over time with increased implant surface, decreased implant volume, and structure thickness; nevertheless, the analyses of visceral organs and biochemistry demonstrated normal results, except for time-dependent iron deposition in the spleen. Therefore, compared with conventional ISs, bioabsorbable iron-based ISs exhibit higher initial mechanical strength. Although iron-based ISs demonstrate high biocompatibility 12 months after implantation, their corrosive iron products may accumulate in the spleen. Because they demonstrate mechanical superiority along with considerable absorption capability after implantation, iron-based ISs may have potential applications in implantable medical-device development in the future. MDPI 2022-11-23 /pmc/articles/PMC9740248/ /pubmed/36498952 http://dx.doi.org/10.3390/ijms232314626 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tai, Chien-Cheng
Huang, Yu-Min
Liaw, Chen-Kun
Yang, Kuo-Yi
Ma, Chun-Hsien
Huang, Shin-I
Huang, Chih-Chieh
Tsai, Pei-I
Shen, Hsin-Hsin
Sun, Jui-Sheng
Chen, Chih-Yu
Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title_full Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title_fullStr Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title_full_unstemmed Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title_short Biocompatibility and Biological Performance of Additive-Manufactured Bioabsorbable Iron-Based Porous Interference Screws in a Rabbit Model: A 1-Year Observational Study
title_sort biocompatibility and biological performance of additive-manufactured bioabsorbable iron-based porous interference screws in a rabbit model: a 1-year observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740248/
https://www.ncbi.nlm.nih.gov/pubmed/36498952
http://dx.doi.org/10.3390/ijms232314626
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