Cargando…

A Novel Huntington’s Disease Assessment Platform to Support Future Drug Discovery and Development

Huntington’s disease (HD) is a lethal neurodegenerative disorder without efficient therapeutic options. The inefficient translation from preclinical and clinical research into clinical use is mainly attributed to the lack of (i) understanding of disease initiation, progression, and involved molecula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Jingyun, Möhle, Luisa, Brüning, Thomas, Eiriz, Iván, Rafehi, Muhammad, Stefan, Katja, Stefan, Sven Marcel, Pahnke, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740291/ https://www.ncbi.nlm.nih.gov/pubmed/36499090 http://dx.doi.org/10.3390/ijms232314763

Ejemplares similares

Time- and Sex-Dependent Effects of Fingolimod Treatment in a Mouse Model of Alzheimer’s Disease
por: Bascuñana, Pablo, et al.
Publicado: (2023)

ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer’s Disease
por: Möhle, Luisa, et al.
Publicado: (2023)

HD_BPMDS: a curated binary pattern multitarget dataset of Huntington’s disease–targeting agents
por: Stefan, Sven Marcel, et al.
Publicado: (2023)

A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds
por: Upīte, Jolanta, et al.
Publicado: (2021)

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
por: Namasivayam, Vigneshwaran, et al.
Publicado: (2021)

Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis
por: Bascuñana, Pablo, et al.
Publicado: (2020)

Structural feature-driven pattern analysis for multitarget modulator landscapes
por: Namasivayam, Vigneshwaran, et al.
Publicado: (2021)

C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors
por: Namasivayam, Vigneshwaran, et al.
Publicado: (2021)

Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA)
por: Namasivayam, Vigneshwaran, et al.
Publicado: (2021)

Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1)
por: Puri, Sachin, et al.
Publicado: (2022)

Detection and Prediction of Mild Cognitive Impairment in Alzheimer’s Disease Mice
por: Rai, Surya Prakash, et al.
Publicado: (2020)

A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors
por: Stefan, Sven Marcel, et al.
Publicado: (2022)

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease
por: Budworth, Helen, et al.
Publicado: (2015)

Gentherapie der Huntington-Krankheit
por: Bräuer, Stefan, et al.
Publicado: (2023)

Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia
por: Bascuñana, Pablo, et al.
Publicado: (2021)

Novel targets for Huntington’s disease: future prospects
por: Mason, Sarah L, et al.
Publicado: (2016)

Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
por: Miller, Ryan A., et al.
Publicado: (2018)

The challenge in translating basic research discoveries to treatment of Huntington disease
por: Mochly-Rosen, Daria, et al.
Publicado: (2014)

Current and Possible Future Therapeutic Options for Huntington’s Disease
por: Ferguson, Mackenzie W., et al.
Publicado: (2022)

Pharmacogenetics in the Treatment of Huntington’s Disease: Review and Future Perspectives
por: García-González, Xandra, et al.
Publicado: (2023)

Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
por: Jensen, Ole, et al.
Publicado: (2021)

A Biosynthetic Platform for Antimalarial Drug Discovery
por: Wilkinson, Mark D., et al.
Publicado: (2020)

An omics perspective on drug target discovery platforms
por: Paananen, Jussi, et al.
Publicado: (2019)

Levoglucosenone: Bio-Based Platform for Drug Discovery
por: Camp, Jason E., et al.
Publicado: (2022)

Alkaloids in Future Drug Discovery
por: Ferreira, Maria-José U.
Publicado: (2022)

Huntington’s Disease: The Past, Present, and Future Search for Disease Modifiers
por: Clabough, Erin B.D.
Publicado: (2013)

Targets for future clinical trials in Huntington's disease: What's in the pipeline?
por: Wild, Edward J, et al.
Publicado: (2014)

How to Capitalize on the Retest Effect in Future Trials on Huntington’s Disease
por: Schramm, Catherine, et al.
Publicado: (2015)

Microfluidic-Based Multi-Organ Platforms for Drug Discovery
por: Rezaei Kolahchi, Ahmad, et al.
Publicado: (2016)

INTUITION: a data platform to integrate human epilepsy clinical care and support for discovery
por: Maharathi, Biswajit, et al.
Publicado: (2023)

An unusual presentation of Huntington’s disease
por: Schulze Westhoff, Martin, et al.
Publicado: (2021)

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3
por: Gebauer, Lukas, et al.
Publicado: (2022)

Intracellular Antibodies for Drug Discovery and as Drugs of the Future
por: Rabbitts, T. H.
Publicado: (2023)

Molecular Strategies to Target Protein Aggregation in Huntington’s Disease
por: Jarosińska, Olga D., et al.
Publicado: (2021)

A meta-analysis of transcriptomic profiles of Huntington’s disease patients
por: Seefelder, Manuel, et al.
Publicado: (2021)

The Future of Platforms
por: Cusumano, Michael
Publicado: (2020)

Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery
por: Klein, Jens, et al.
Publicado: (2014)

Enroll-HD: An Integrated Clinical Research Platform and Worldwide Observational Study for Huntington's Disease
por: Sathe, Swati, et al.
Publicado: (2021)

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
por: Moraes, Carolina B., et al.
Publicado: (2019)

Irritability in pre-clinical Huntington's disease
por: Klöppel, Stefan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_2o7d5e05hm9mska6b0mtnh6l1f