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The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study
Purpose: Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. Methods: In this retrospective cohort study, previously recruited 1,40...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740381/ https://www.ncbi.nlm.nih.gov/pubmed/36399107 http://dx.doi.org/10.18632/aging.204393 |
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author | Yamanashi, Takehiko Anderson, Zoe-Ella EM Modukuri, Manisha Chang, Gloria Tran, Tammy Marra, Pedro S. Wahba, Nadia E. Crutchley, Kaitlyn J. Sullivan, Eleanor J. Jellison, Sydney S. Comp, Katie R. Akers, Cade C. Meyer, Alissa A. Lee, Sangil Iwata, Masaaki Cho, Hyunkeun R. Shinozaki, Eri Shinozaki, Gen |
author_facet | Yamanashi, Takehiko Anderson, Zoe-Ella EM Modukuri, Manisha Chang, Gloria Tran, Tammy Marra, Pedro S. Wahba, Nadia E. Crutchley, Kaitlyn J. Sullivan, Eleanor J. Jellison, Sydney S. Comp, Katie R. Akers, Cade C. Meyer, Alissa A. Lee, Sangil Iwata, Masaaki Cho, Hyunkeun R. Shinozaki, Eri Shinozaki, Gen |
author_sort | Yamanashi, Takehiko |
collection | PubMed |
description | Purpose: Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. Methods: In this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. Main findings: 242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). Conclusions: Metformin use may lower the risk of delirium and mortality in DM patients. |
format | Online Article Text |
id | pubmed-9740381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-97403812022-12-12 The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study Yamanashi, Takehiko Anderson, Zoe-Ella EM Modukuri, Manisha Chang, Gloria Tran, Tammy Marra, Pedro S. Wahba, Nadia E. Crutchley, Kaitlyn J. Sullivan, Eleanor J. Jellison, Sydney S. Comp, Katie R. Akers, Cade C. Meyer, Alissa A. Lee, Sangil Iwata, Masaaki Cho, Hyunkeun R. Shinozaki, Eri Shinozaki, Gen Aging (Albany NY) Research Paper Purpose: Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality. Methods: In this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. Main findings: 242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]). Conclusions: Metformin use may lower the risk of delirium and mortality in DM patients. Impact Journals 2022-11-17 /pmc/articles/PMC9740381/ /pubmed/36399107 http://dx.doi.org/10.18632/aging.204393 Text en Copyright: © 2022 Yamanashi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yamanashi, Takehiko Anderson, Zoe-Ella EM Modukuri, Manisha Chang, Gloria Tran, Tammy Marra, Pedro S. Wahba, Nadia E. Crutchley, Kaitlyn J. Sullivan, Eleanor J. Jellison, Sydney S. Comp, Katie R. Akers, Cade C. Meyer, Alissa A. Lee, Sangil Iwata, Masaaki Cho, Hyunkeun R. Shinozaki, Eri Shinozaki, Gen The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title_full | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title_fullStr | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title_full_unstemmed | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title_short | The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
title_sort | potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740381/ https://www.ncbi.nlm.nih.gov/pubmed/36399107 http://dx.doi.org/10.18632/aging.204393 |
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