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Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study

Inflammation is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occur...

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Autores principales: Teixeira, Leonardo Augusto Costa, dos Santos, Jousielle Marcia, Parentoni, Adriana Netto, Lima, Liliana Pereira, Duarte, Tamiris Campos, Brant, Franciane Pereira, Neves, Camila Danielle Cunha, Pereira, Fabiana Souza Máximo, Avelar, Núbia Carelli Pereira, Danielewicz, Ana Lucia, Leopoldino, Amanda Aparecida Oliveira, Costa, Sabrina Paula, Arrieiro, Arthur Nascimento, Soares, Luana Aparecida, Prates, Ana Caroline Negreiros, Nobre, Juliana Nogueira Pontes, de Carvalho Bastone, Alessandra, de Oliveira, Vinicius Cunha, Oliveira, Murilo Xavier, Scheidt Figueiredo, Pedro Henrique, Costa, Henrique Silveira, Amaral Mendonça, Vanessa, Taiar, Redha, Rodrigues Lacerda, Ana Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740541/
https://www.ncbi.nlm.nih.gov/pubmed/36498747
http://dx.doi.org/10.3390/jcm11237175
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author Teixeira, Leonardo Augusto Costa
dos Santos, Jousielle Marcia
Parentoni, Adriana Netto
Lima, Liliana Pereira
Duarte, Tamiris Campos
Brant, Franciane Pereira
Neves, Camila Danielle Cunha
Pereira, Fabiana Souza Máximo
Avelar, Núbia Carelli Pereira
Danielewicz, Ana Lucia
Leopoldino, Amanda Aparecida Oliveira
Costa, Sabrina Paula
Arrieiro, Arthur Nascimento
Soares, Luana Aparecida
Prates, Ana Caroline Negreiros
Nobre, Juliana Nogueira Pontes
de Carvalho Bastone, Alessandra
de Oliveira, Vinicius Cunha
Oliveira, Murilo Xavier
Scheidt Figueiredo, Pedro Henrique
Costa, Henrique Silveira
Amaral Mendonça, Vanessa
Taiar, Redha
Rodrigues Lacerda, Ana Cristina
author_facet Teixeira, Leonardo Augusto Costa
dos Santos, Jousielle Marcia
Parentoni, Adriana Netto
Lima, Liliana Pereira
Duarte, Tamiris Campos
Brant, Franciane Pereira
Neves, Camila Danielle Cunha
Pereira, Fabiana Souza Máximo
Avelar, Núbia Carelli Pereira
Danielewicz, Ana Lucia
Leopoldino, Amanda Aparecida Oliveira
Costa, Sabrina Paula
Arrieiro, Arthur Nascimento
Soares, Luana Aparecida
Prates, Ana Caroline Negreiros
Nobre, Juliana Nogueira Pontes
de Carvalho Bastone, Alessandra
de Oliveira, Vinicius Cunha
Oliveira, Murilo Xavier
Scheidt Figueiredo, Pedro Henrique
Costa, Henrique Silveira
Amaral Mendonça, Vanessa
Taiar, Redha
Rodrigues Lacerda, Ana Cristina
author_sort Teixeira, Leonardo Augusto Costa
collection PubMed
description Inflammation is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occurrence have emerged. To aid diagnostic and treatment strategies for low muscle mass in sarcopenia and other related conditions, the objective of this work was to investigate potential biomarkers associated with appendicular lean mass in community-dwelling older women. This is a cross-sectional study with 71 older women (75 ± 7 years). Dual-energy X-ray absorptiometry was used to assess body composition. Plasmatic blood levels of adipokines (i.e., adiponectin, leptin, and resistin), tumor necrosis factor (TNF) and soluble receptors (sTNFr1 and sTNFr2), interferon (INF), brain-derived neurotrophic factor (BDNF), and interleukins (IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10) were determined by enzyme-linked immunosorbent assay. Older women with low muscle mass showed higher plasma levels of adiponectin, sTNFr1, and IL-8 compared to the regular muscle mass group. In addition, higher adiponectin plasma levels explained 14% of the lower appendicular lean mass. High adiponectin plasmatic blood levels can contribute to lower appendicular lean mass in older, community-dwelling women.
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spelling pubmed-97405412022-12-11 Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study Teixeira, Leonardo Augusto Costa dos Santos, Jousielle Marcia Parentoni, Adriana Netto Lima, Liliana Pereira Duarte, Tamiris Campos Brant, Franciane Pereira Neves, Camila Danielle Cunha Pereira, Fabiana Souza Máximo Avelar, Núbia Carelli Pereira Danielewicz, Ana Lucia Leopoldino, Amanda Aparecida Oliveira Costa, Sabrina Paula Arrieiro, Arthur Nascimento Soares, Luana Aparecida Prates, Ana Caroline Negreiros Nobre, Juliana Nogueira Pontes de Carvalho Bastone, Alessandra de Oliveira, Vinicius Cunha Oliveira, Murilo Xavier Scheidt Figueiredo, Pedro Henrique Costa, Henrique Silveira Amaral Mendonça, Vanessa Taiar, Redha Rodrigues Lacerda, Ana Cristina J Clin Med Article Inflammation is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occurrence have emerged. To aid diagnostic and treatment strategies for low muscle mass in sarcopenia and other related conditions, the objective of this work was to investigate potential biomarkers associated with appendicular lean mass in community-dwelling older women. This is a cross-sectional study with 71 older women (75 ± 7 years). Dual-energy X-ray absorptiometry was used to assess body composition. Plasmatic blood levels of adipokines (i.e., adiponectin, leptin, and resistin), tumor necrosis factor (TNF) and soluble receptors (sTNFr1 and sTNFr2), interferon (INF), brain-derived neurotrophic factor (BDNF), and interleukins (IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10) were determined by enzyme-linked immunosorbent assay. Older women with low muscle mass showed higher plasma levels of adiponectin, sTNFr1, and IL-8 compared to the regular muscle mass group. In addition, higher adiponectin plasma levels explained 14% of the lower appendicular lean mass. High adiponectin plasmatic blood levels can contribute to lower appendicular lean mass in older, community-dwelling women. MDPI 2022-12-02 /pmc/articles/PMC9740541/ /pubmed/36498747 http://dx.doi.org/10.3390/jcm11237175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Teixeira, Leonardo Augusto Costa
dos Santos, Jousielle Marcia
Parentoni, Adriana Netto
Lima, Liliana Pereira
Duarte, Tamiris Campos
Brant, Franciane Pereira
Neves, Camila Danielle Cunha
Pereira, Fabiana Souza Máximo
Avelar, Núbia Carelli Pereira
Danielewicz, Ana Lucia
Leopoldino, Amanda Aparecida Oliveira
Costa, Sabrina Paula
Arrieiro, Arthur Nascimento
Soares, Luana Aparecida
Prates, Ana Caroline Negreiros
Nobre, Juliana Nogueira Pontes
de Carvalho Bastone, Alessandra
de Oliveira, Vinicius Cunha
Oliveira, Murilo Xavier
Scheidt Figueiredo, Pedro Henrique
Costa, Henrique Silveira
Amaral Mendonça, Vanessa
Taiar, Redha
Rodrigues Lacerda, Ana Cristina
Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title_full Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title_fullStr Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title_full_unstemmed Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title_short Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
title_sort adiponectin is a contributing factor of low appendicular lean mass in older community-dwelling women: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740541/
https://www.ncbi.nlm.nih.gov/pubmed/36498747
http://dx.doi.org/10.3390/jcm11237175
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