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Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System
The overuse of antibiotics has led to severe bacterial drug resistance. Blocking pathogen virulence devices is a highly effective approach to combating bacterial resistance worldwide. Type three secretion systems (T3SSs) are significant virulence factors in Gram-negative pathogens. Inhibition of the...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740592/ https://www.ncbi.nlm.nih.gov/pubmed/36500441 http://dx.doi.org/10.3390/molecules27238348 |
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author | Lv, Chao Li, Ying Wei, Yuxia Wang, Jiayu Yu, Hui Gao, Feng Zhu, Chao Jia, Xiangdi Tong, Mingqiong Dong, Pingxuan Gao, Qianqian Geng, Longlong |
author_facet | Lv, Chao Li, Ying Wei, Yuxia Wang, Jiayu Yu, Hui Gao, Feng Zhu, Chao Jia, Xiangdi Tong, Mingqiong Dong, Pingxuan Gao, Qianqian Geng, Longlong |
author_sort | Lv, Chao |
collection | PubMed |
description | The overuse of antibiotics has led to severe bacterial drug resistance. Blocking pathogen virulence devices is a highly effective approach to combating bacterial resistance worldwide. Type three secretion systems (T3SSs) are significant virulence factors in Gram-negative pathogens. Inhibition of these systems can effectively weaken infection whilst having no significant effect on bacterial growth. Therefore, T3SS inhibitors may be a powerful weapon against resistance in Gram-negative bacteria, and there has been increasing interest in the research and development of T3SS inhibitors. This review outlines several reported small-molecule inhibitors of the T3SS, covering those of synthetic and natural origin, including their sources, structures, and mechanisms of action. |
format | Online Article Text |
id | pubmed-9740592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97405922022-12-11 Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System Lv, Chao Li, Ying Wei, Yuxia Wang, Jiayu Yu, Hui Gao, Feng Zhu, Chao Jia, Xiangdi Tong, Mingqiong Dong, Pingxuan Gao, Qianqian Geng, Longlong Molecules Review The overuse of antibiotics has led to severe bacterial drug resistance. Blocking pathogen virulence devices is a highly effective approach to combating bacterial resistance worldwide. Type three secretion systems (T3SSs) are significant virulence factors in Gram-negative pathogens. Inhibition of these systems can effectively weaken infection whilst having no significant effect on bacterial growth. Therefore, T3SS inhibitors may be a powerful weapon against resistance in Gram-negative bacteria, and there has been increasing interest in the research and development of T3SS inhibitors. This review outlines several reported small-molecule inhibitors of the T3SS, covering those of synthetic and natural origin, including their sources, structures, and mechanisms of action. MDPI 2022-11-30 /pmc/articles/PMC9740592/ /pubmed/36500441 http://dx.doi.org/10.3390/molecules27238348 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lv, Chao Li, Ying Wei, Yuxia Wang, Jiayu Yu, Hui Gao, Feng Zhu, Chao Jia, Xiangdi Tong, Mingqiong Dong, Pingxuan Gao, Qianqian Geng, Longlong Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title | Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title_full | Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title_fullStr | Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title_full_unstemmed | Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title_short | Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System |
title_sort | research progress on small molecular inhibitors of the type 3 secretion system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740592/ https://www.ncbi.nlm.nih.gov/pubmed/36500441 http://dx.doi.org/10.3390/molecules27238348 |
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