Cargando…

Digital Quantification of Intratumoral CD8+ T-Cells Predicts Relapse and Unfavorable Outcome in Uveal Melanoma

SIMPLE SUMMARY: In this study, we used digital pathology and image analysis for the prediction of the prognosis in uveal melanoma (UM). We retrospectively evaluated a total of 404 histopathological slides of 101 patients. Immune biomarkers for CD4, CD8, CD68, and CD163 were performed and evaluated b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hurdogan, Ozge, De Logu, Francesco, Galli, Francesca, Tuncer, Samuray, Ugolini, Filippo, Simi, Sara, Portelli, Francesca, Nassini, Romina, Massi, Daniela, Buyukbabani, Nesimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740732/ https://www.ncbi.nlm.nih.gov/pubmed/36497441 http://dx.doi.org/10.3390/cancers14235959

Ejemplares similares

TRPA1 Expression in Synovial Sarcoma May Support Neural Origin
por: De Logu, Francesco, et al.
Publicado: (2020)

Secondary Localized Cutaneous Amyloidosis is not Rare in Bowen’s Disease and Bowenoid Papulosis
por: Baykal, Can, et al.
Publicado: (2022)

A Fast and Automated Melanin-bleaching Method for Histopathologic Evaluation of Pigmented Melanoma Tissues
por: Ugolini, Filippo, et al.
Publicado: (2022)

Recognition of Cutaneous Melanoma on Digitized Histopathological Slides via Artificial Intelligence Algorithm
por: De Logu, Francesco, et al.
Publicado: (2020)

Digital Immunophenotyping Predicts Disease Free and Overall Survival in Early Stage Melanoma Patients
por: De Logu, Francesco, et al.
Publicado: (2021)

BRAF, NRAS, KIT, TERT, GNAQ/GNA11 Mutation Profile and Histomorphological Analysis of Anorectal Melanomas: A Clinicopathologic Study
por: Taskın, Orhun Cig, et al.
Publicado: (2023)

The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma
por: De Logu, Francesco, et al.
Publicado: (2021)

Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties
por: Audrito, Valentina, et al.
Publicado: (2022)

Intratumor Heterogeneity in Uveal Melanoma BAP-1 Expression
por: Stålhammar, Gustav, et al.
Publicado: (2021)

Intratumoral bacteria in uveal melanoma: A case report
por: Vega Escobar, Katherine, et al.
Publicado: (2023)

TRPA1 as a therapeutic target for nociceptive pain
por: Souza Monteiro de Araujo, Daniel, et al.
Publicado: (2020)

The Spectrum of Underlying Causes of Iatrogenic Kaposi's Sarcoma in a Large Series: A Retrospective Study
por: Baykal, Can, et al.
Publicado: (2019)

Recalcitrant vegetative and nodular scalp lesions on the vertex in pemphigus patients: an immunocompromised district?()
por: Kucukoglu, Rifkiye, et al.
Publicado: (2023)

Circulating Tumor Cells Detection and Counting in Uveal Melanomas by a Filtration-Based Method
por: Mazzini, Cinzia, et al.
Publicado: (2014)

Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma
por: Dogrusöz, Mehmet, et al.
Publicado: (2019)

Two Clinically Unusual Cases of Folliculotropic Mycosis Fungoides: One with and the Other without Syringotropism
por: Bakar, Özgür, et al.
Publicado: (2014)

The Dilemma of Coexisting Nevoid Hyperkeratosis of the Nipple and Areola in Mycosis Fungoides: A Report of Three Cases
por: Polat Ekinci, Algun, et al.
Publicado: (2015)

Evaluation of Associated Lymphomas and Their Risk Factors in Patients with Lymphomatoid Papulosis: A Retrospective Single- Center Study from Turkey
por: Baykal, Can, et al.
Publicado: (2021)

The Role of TRPA1 in Skin Physiology and Pathology
por: Maglie, Roberto, et al.
Publicado: (2021)

TRPA1 Role in Inflammatory Disorders: What Is Known So Far?
por: Landini, Lorenzo, et al.
Publicado: (2022)

TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches
por: Marini, Matilde, et al.
Publicado: (2023)

Dramatic Regression of Presumed Acquired Retinal Astrocytoma with Photodynamic Therapy
por: Tuncer, Samuray, et al.
Publicado: (2014)

Bright-Field Multiplex Immunohistochemistry Assay for Tumor Microenvironment Evaluation in Melanoma Tissues
por: Ugolini, Filippo, et al.
Publicado: (2022)

Choroidal neovascularization secondary to choroidal nevus simulating an inflammatory lesion
por: Tuncer, Samuray, et al.
Publicado: (2013)

Migraine-provoking substances evoke periorbital allodynia in mice
por: De Logu, Francesco, et al.
Publicado: (2019)

Case of Olmsted Syndrome with Essential Thrombocytosis Misdiagnosed as Acrodermatitis Enteropathica
por: Demir, Filiz Topaloğlu, et al.
Publicado: (2021)

Pediatric Case of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Rare Entity
por: Gündüz, Mehmet, et al.
Publicado: (2022)

Intratumoral neutrophil extracellular traps are associated with unfavorable clinical outcomes and immunogenic context in pancreatic ductal adenocarcinoma
por: Chen, Xianlong, et al.
Publicado: (2022)

Regression of conjunctival tumor during dietary treatment of celiac disease
por: Tuncer, Samuray, et al.
Publicado: (2010)

Clinical Features and Long-Term Follow-Up of Patients with Retinoblastoma in Turkish Children Older Than 5 Years of Age
por: Cebeci, Zafer, et al.
Publicado: (2020)

Annular Erythematous Patches as the Presenting Sign of Extranodal Natural Killer/T-Cell Lymphoma
por: Baykal, Can, et al.
Publicado: (2016)

The biology of uveal melanoma
por: Amaro, Adriana, et al.
Publicado: (2017)

Granulomatous Dermatitis and Systemic Disease: An Association to Consider
por: Corrà, Alberto, et al.
Publicado: (2020)

Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine
por: Landini, Lorenzo, et al.
Publicado: (2023)

The density and spatial tissue distribution of CD8(+) and CD163(+) immune cells predict response and outcome in melanoma patients receiving MAPK inhibitors
por: Massi, Daniela, et al.
Publicado: (2019)

β2-and β3-Adrenergic Receptors Contribute to Cancer-Evoked Pain in a Mouse Model of Osteosarcoma via Modulation of Neural Macrophages
por: Bruno, Gennaro, et al.
Publicado: (2021)

Isolated form of congenital bilateral lacrimal gland agenesis
por: Sahinoglu, Nedime, et al.
Publicado: (2011)

Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors
por: Suhovskih, Anastasia V., et al.
Publicado: (2020)

Could “Islets of Sparing” Be a Clue for Neutral Lipid Storage Disease with Ichthyosis in Patients with Congenital Ichthyosiform Erythroderma?
por: Demir, Filiz Topaloglu, et al.
Publicado: (2022)

Massive Uveal Relapse of Retinoblastoma Presumed to Be Choroidal Tumorous Involvement: Case Series
por: Ghassemi, Fariba, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_el48kbr9te71de6nt4ptf8b5mo