Cargando…

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Orrù, Stefania, Imperlini, Esther, Vitucci, Daniela, Caterino, Marianna, Mandola, Annalisa, Randers, Morten Bredsgaard, Schmidt, Jakob Friis, Hagman, Marie, Andersen, Thomas Rostgaard, Krustrup, Peter, Ruoppolo, Margherita, Buono, Pasqualina, Mancini, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740844/
https://www.ncbi.nlm.nih.gov/pubmed/36497910
http://dx.doi.org/10.3390/ijerph192315835
Descripción
Sumario:Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.