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Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740844/ https://www.ncbi.nlm.nih.gov/pubmed/36497910 http://dx.doi.org/10.3390/ijerph192315835 |
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author | Orrù, Stefania Imperlini, Esther Vitucci, Daniela Caterino, Marianna Mandola, Annalisa Randers, Morten Bredsgaard Schmidt, Jakob Friis Hagman, Marie Andersen, Thomas Rostgaard Krustrup, Peter Ruoppolo, Margherita Buono, Pasqualina Mancini, Annamaria |
author_facet | Orrù, Stefania Imperlini, Esther Vitucci, Daniela Caterino, Marianna Mandola, Annalisa Randers, Morten Bredsgaard Schmidt, Jakob Friis Hagman, Marie Andersen, Thomas Rostgaard Krustrup, Peter Ruoppolo, Margherita Buono, Pasqualina Mancini, Annamaria |
author_sort | Orrù, Stefania |
collection | PubMed |
description | Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging. |
format | Online Article Text |
id | pubmed-9740844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97408442022-12-11 Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players Orrù, Stefania Imperlini, Esther Vitucci, Daniela Caterino, Marianna Mandola, Annalisa Randers, Morten Bredsgaard Schmidt, Jakob Friis Hagman, Marie Andersen, Thomas Rostgaard Krustrup, Peter Ruoppolo, Margherita Buono, Pasqualina Mancini, Annamaria Int J Environ Res Public Health Article Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging. MDPI 2022-11-28 /pmc/articles/PMC9740844/ /pubmed/36497910 http://dx.doi.org/10.3390/ijerph192315835 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Orrù, Stefania Imperlini, Esther Vitucci, Daniela Caterino, Marianna Mandola, Annalisa Randers, Morten Bredsgaard Schmidt, Jakob Friis Hagman, Marie Andersen, Thomas Rostgaard Krustrup, Peter Ruoppolo, Margherita Buono, Pasqualina Mancini, Annamaria Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title | Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title_full | Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title_fullStr | Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title_full_unstemmed | Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title_short | Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players |
title_sort | insight into the molecular signature of skeletal muscle characterizing lifelong football players |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740844/ https://www.ncbi.nlm.nih.gov/pubmed/36497910 http://dx.doi.org/10.3390/ijerph192315835 |
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