Cargando…

Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Orrù, Stefania, Imperlini, Esther, Vitucci, Daniela, Caterino, Marianna, Mandola, Annalisa, Randers, Morten Bredsgaard, Schmidt, Jakob Friis, Hagman, Marie, Andersen, Thomas Rostgaard, Krustrup, Peter, Ruoppolo, Margherita, Buono, Pasqualina, Mancini, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740844/
https://www.ncbi.nlm.nih.gov/pubmed/36497910
http://dx.doi.org/10.3390/ijerph192315835
_version_ 1784848167265632256
author Orrù, Stefania
Imperlini, Esther
Vitucci, Daniela
Caterino, Marianna
Mandola, Annalisa
Randers, Morten Bredsgaard
Schmidt, Jakob Friis
Hagman, Marie
Andersen, Thomas Rostgaard
Krustrup, Peter
Ruoppolo, Margherita
Buono, Pasqualina
Mancini, Annamaria
author_facet Orrù, Stefania
Imperlini, Esther
Vitucci, Daniela
Caterino, Marianna
Mandola, Annalisa
Randers, Morten Bredsgaard
Schmidt, Jakob Friis
Hagman, Marie
Andersen, Thomas Rostgaard
Krustrup, Peter
Ruoppolo, Margherita
Buono, Pasqualina
Mancini, Annamaria
author_sort Orrù, Stefania
collection PubMed
description Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.
format Online
Article
Text
id pubmed-9740844
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97408442022-12-11 Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players Orrù, Stefania Imperlini, Esther Vitucci, Daniela Caterino, Marianna Mandola, Annalisa Randers, Morten Bredsgaard Schmidt, Jakob Friis Hagman, Marie Andersen, Thomas Rostgaard Krustrup, Peter Ruoppolo, Margherita Buono, Pasqualina Mancini, Annamaria Int J Environ Res Public Health Article Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging. MDPI 2022-11-28 /pmc/articles/PMC9740844/ /pubmed/36497910 http://dx.doi.org/10.3390/ijerph192315835 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Orrù, Stefania
Imperlini, Esther
Vitucci, Daniela
Caterino, Marianna
Mandola, Annalisa
Randers, Morten Bredsgaard
Schmidt, Jakob Friis
Hagman, Marie
Andersen, Thomas Rostgaard
Krustrup, Peter
Ruoppolo, Margherita
Buono, Pasqualina
Mancini, Annamaria
Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title_full Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title_fullStr Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title_full_unstemmed Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title_short Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
title_sort insight into the molecular signature of skeletal muscle characterizing lifelong football players
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740844/
https://www.ncbi.nlm.nih.gov/pubmed/36497910
http://dx.doi.org/10.3390/ijerph192315835
work_keys_str_mv AT orrustefania insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT imperliniesther insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT vituccidaniela insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT caterinomarianna insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT mandolaannalisa insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT randersmortenbredsgaard insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT schmidtjakobfriis insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT hagmanmarie insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT andersenthomasrostgaard insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT krustruppeter insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT ruoppolomargherita insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT buonopasqualina insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers
AT manciniannamaria insightintothemolecularsignatureofskeletalmusclecharacterizinglifelongfootballplayers