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The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator

The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the compo...

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Autores principales: Hu, Xiangdong, Jin, Xuejiao, Cao, Xiuling, Liu, Beidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740938/
https://www.ncbi.nlm.nih.gov/pubmed/36499653
http://dx.doi.org/10.3390/ijms232315327
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author Hu, Xiangdong
Jin, Xuejiao
Cao, Xiuling
Liu, Beidong
author_facet Hu, Xiangdong
Jin, Xuejiao
Cao, Xiuling
Liu, Beidong
author_sort Hu, Xiangdong
collection PubMed
description The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified and characterized. Given the close relationship between the cell cycle and lifespan, it is urgent to understand the roles of APC/C in lifespan regulation, but this field still seems to have not been systematically summarized. Furthermore, although several reviews have reported the roles of APC/C in cancer, there are still gaps in the summary of its roles in other age-related diseases. In this review, we propose that the APC/C is a novel cellular ageing regulator based on its indispensable role in the regulation of lifespan and its involvement in age-associated diseases. This work provides an extensive review of aspects related to the underlying mechanisms of APC/C in lifespan regulation and how it participates in age-associated diseases. More comprehensive recognition and understanding of the relationship between APC/C and ageing and age-related diseases will increase the development of targeted strategies for human health.
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spelling pubmed-97409382022-12-11 The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator Hu, Xiangdong Jin, Xuejiao Cao, Xiuling Liu, Beidong Int J Mol Sci Review The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified and characterized. Given the close relationship between the cell cycle and lifespan, it is urgent to understand the roles of APC/C in lifespan regulation, but this field still seems to have not been systematically summarized. Furthermore, although several reviews have reported the roles of APC/C in cancer, there are still gaps in the summary of its roles in other age-related diseases. In this review, we propose that the APC/C is a novel cellular ageing regulator based on its indispensable role in the regulation of lifespan and its involvement in age-associated diseases. This work provides an extensive review of aspects related to the underlying mechanisms of APC/C in lifespan regulation and how it participates in age-associated diseases. More comprehensive recognition and understanding of the relationship between APC/C and ageing and age-related diseases will increase the development of targeted strategies for human health. MDPI 2022-12-05 /pmc/articles/PMC9740938/ /pubmed/36499653 http://dx.doi.org/10.3390/ijms232315327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Xiangdong
Jin, Xuejiao
Cao, Xiuling
Liu, Beidong
The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title_full The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title_fullStr The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title_full_unstemmed The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title_short The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator
title_sort anaphase-promoting complex/cyclosome is a cellular ageing regulator
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9740938/
https://www.ncbi.nlm.nih.gov/pubmed/36499653
http://dx.doi.org/10.3390/ijms232315327
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