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Synthesis, In Silico and In Vivo Toxicity Assessment of Functionalized Pyridophenanthridinones via Sequential MW-Assisted Intramolecular Friedel-Crafts Alkylation and Direct C–H Arylation

A rapid, efficient, and original synthesis of novel pyrido[3,2,1-de]phenanthridin-6-ones is reported. First, the key cinnamamide intermediates 8a–f were easily prepared from commercial substituted anilines, cinnamic acid, and 2-bromobenzylbromide in a tandem amidation and N-alkylation protocol. Then...

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Detalles Bibliográficos
Autores principales:	Ortiz Villamizar, Marlyn C., Puerto Galvis, Carlos E., Pedraza Rodríguez, Silvia A., Zubkov, Fedor I., Kouznetsov, Vladimir V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741109/ https://www.ncbi.nlm.nih.gov/pubmed/36500206 http://dx.doi.org/10.3390/molecules27238112

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