Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells

Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti(65)-Zr(18)-Nb(16)-Mo(1) (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, t...

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Autores principales: Ho, Wen-Fu, Wong, Ka-Kin, Lee, Mei-Hwa, Thomas, James L., Chang, Ya-Chun, Wu, Shih-Ching, Hsu, Hsueh-Chuan, Lin, Hung-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741175/
https://www.ncbi.nlm.nih.gov/pubmed/36498880
http://dx.doi.org/10.3390/ijms232314552
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author Ho, Wen-Fu
Wong, Ka-Kin
Lee, Mei-Hwa
Thomas, James L.
Chang, Ya-Chun
Wu, Shih-Ching
Hsu, Hsueh-Chuan
Lin, Hung-Yin
author_facet Ho, Wen-Fu
Wong, Ka-Kin
Lee, Mei-Hwa
Thomas, James L.
Chang, Ya-Chun
Wu, Shih-Ching
Hsu, Hsueh-Chuan
Lin, Hung-Yin
author_sort Ho, Wen-Fu
collection PubMed
description Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti(65)-Zr(18)-Nb(16)-Mo(1) (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the titanium alloys were measured, and the correlation with the cellular viability was investigated. Finally, the relative protein expression in cellular proliferation pathways was measured and compared with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR).
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spelling pubmed-97411752022-12-11 Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells Ho, Wen-Fu Wong, Ka-Kin Lee, Mei-Hwa Thomas, James L. Chang, Ya-Chun Wu, Shih-Ching Hsu, Hsueh-Chuan Lin, Hung-Yin Int J Mol Sci Communication Titanium and titanium alloys are widely used in medical devices and implants; thus, the biocompatibility of these metals is of great importance. In this study, glioblastoma astrocytoma cellular responses to Ti(65)-Zr(18)-Nb(16)-Mo(1) (Ti65M, metastable medium-entropy alloy), Ti-13Nb-7Sn-4Mo (TNSM, titanium alloy), and commercially pure titanium (CP-Ti) were studied. Several physical parameters (crystal phase structure, surface roughness and hardness) of the titanium alloys were measured, and the correlation with the cellular viability was investigated. Finally, the relative protein expression in cellular proliferation pathways was measured and compared with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR). MDPI 2022-11-22 /pmc/articles/PMC9741175/ /pubmed/36498880 http://dx.doi.org/10.3390/ijms232314552 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ho, Wen-Fu
Wong, Ka-Kin
Lee, Mei-Hwa
Thomas, James L.
Chang, Ya-Chun
Wu, Shih-Ching
Hsu, Hsueh-Chuan
Lin, Hung-Yin
Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title_full Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title_fullStr Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title_full_unstemmed Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title_short Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
title_sort biocompatibility of a ti-rich medium-entropy alloy with glioblastoma astrocytoma cells
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741175/
https://www.ncbi.nlm.nih.gov/pubmed/36498880
http://dx.doi.org/10.3390/ijms232314552
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