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Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature

Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken int...

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Autores principales: Westphal, Dominik S., Hauser, Michael, Beckmann, Britt-Maria, Wolf, Cordula M., Hessling, Gabriele, Oberhoffer-Fritz, Renate, Wacker-Gussmann, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741304/
https://www.ncbi.nlm.nih.gov/pubmed/36498454
http://dx.doi.org/10.3390/jcm11236880
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author Westphal, Dominik S.
Hauser, Michael
Beckmann, Britt-Maria
Wolf, Cordula M.
Hessling, Gabriele
Oberhoffer-Fritz, Renate
Wacker-Gussmann, Annette
author_facet Westphal, Dominik S.
Hauser, Michael
Beckmann, Britt-Maria
Wolf, Cordula M.
Hessling, Gabriele
Oberhoffer-Fritz, Renate
Wacker-Gussmann, Annette
author_sort Westphal, Dominik S.
collection PubMed
description Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases.
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spelling pubmed-97413042022-12-11 Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature Westphal, Dominik S. Hauser, Michael Beckmann, Britt-Maria Wolf, Cordula M. Hessling, Gabriele Oberhoffer-Fritz, Renate Wacker-Gussmann, Annette J Clin Med Review Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases. MDPI 2022-11-22 /pmc/articles/PMC9741304/ /pubmed/36498454 http://dx.doi.org/10.3390/jcm11236880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Westphal, Dominik S.
Hauser, Michael
Beckmann, Britt-Maria
Wolf, Cordula M.
Hessling, Gabriele
Oberhoffer-Fritz, Renate
Wacker-Gussmann, Annette
Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title_full Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title_fullStr Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title_full_unstemmed Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title_short Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature
title_sort fetal bradycardia caused by monogenic disorders—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741304/
https://www.ncbi.nlm.nih.gov/pubmed/36498454
http://dx.doi.org/10.3390/jcm11236880
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