Cargando…
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator
LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphory...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741313/ https://www.ncbi.nlm.nih.gov/pubmed/36497077 http://dx.doi.org/10.3390/cells11233817 |
_version_ | 1784848288605798400 |
---|---|
author | Butt, Elke Howard, Cory M. Raman, Dayanidhi |
author_facet | Butt, Elke Howard, Cory M. Raman, Dayanidhi |
author_sort | Butt, Elke |
collection | PubMed |
description | LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More specifically, we will describe the role of LASP1 in chemokine receptor, and PI3K/AKT signaling. We outline the nuclear role for LASP1 in terms of epigenetics and transcriptional regulation and modulation of oncogenic mRNA translation. Finally, newly identified roles for the cytoskeletal function of LASP1 next to its known canonical F-actin binding properties are included. |
format | Online Article Text |
id | pubmed-9741313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97413132022-12-11 LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator Butt, Elke Howard, Cory M. Raman, Dayanidhi Cells Review LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More specifically, we will describe the role of LASP1 in chemokine receptor, and PI3K/AKT signaling. We outline the nuclear role for LASP1 in terms of epigenetics and transcriptional regulation and modulation of oncogenic mRNA translation. Finally, newly identified roles for the cytoskeletal function of LASP1 next to its known canonical F-actin binding properties are included. MDPI 2022-11-29 /pmc/articles/PMC9741313/ /pubmed/36497077 http://dx.doi.org/10.3390/cells11233817 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Butt, Elke Howard, Cory M. Raman, Dayanidhi LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title | LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title_full | LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title_fullStr | LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title_full_unstemmed | LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title_short | LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator |
title_sort | lasp1 in cellular signaling and gene expression: more than just a cytoskeletal regulator |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741313/ https://www.ncbi.nlm.nih.gov/pubmed/36497077 http://dx.doi.org/10.3390/cells11233817 |
work_keys_str_mv | AT buttelke lasp1incellularsignalingandgeneexpressionmorethanjustacytoskeletalregulator AT howardcorym lasp1incellularsignalingandgeneexpressionmorethanjustacytoskeletalregulator AT ramandayanidhi lasp1incellularsignalingandgeneexpressionmorethanjustacytoskeletalregulator |