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The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line

The existence of a tight relationship between inflammation and epigenetics that in primary breast tumor cells can lead to tumor progression and the formation of bone metastases was investigated. It was highlighted how the induction of tumor progression and bone metastasis by Interleukin-1 beta, in a...

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Autores principales: Bellavia, Daniele, Costa, Viviana, De Luca, Angela, Cordaro, Aurora, Fini, Milena, Giavaresi, Gianluca, Caradonna, Fabio, Raimondi, Lavinia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741332/
https://www.ncbi.nlm.nih.gov/pubmed/36499741
http://dx.doi.org/10.3390/ijms232315422
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author Bellavia, Daniele
Costa, Viviana
De Luca, Angela
Cordaro, Aurora
Fini, Milena
Giavaresi, Gianluca
Caradonna, Fabio
Raimondi, Lavinia
author_facet Bellavia, Daniele
Costa, Viviana
De Luca, Angela
Cordaro, Aurora
Fini, Milena
Giavaresi, Gianluca
Caradonna, Fabio
Raimondi, Lavinia
author_sort Bellavia, Daniele
collection PubMed
description The existence of a tight relationship between inflammation and epigenetics that in primary breast tumor cells can lead to tumor progression and the formation of bone metastases was investigated. It was highlighted how the induction of tumor progression and bone metastasis by Interleukin-1 beta, in a non-metastatic breast cancer cell line, MCF-7, was dependent on the de-methylating actions of ten-eleven translocation proteins (TETs). In fact, the inhibition of their activity by the Bobcat339 molecule, an inhibitor of TET enzymes, determined on the one hand, the modulation of the epithelial-mesenchymal transition process, and on the other hand, the reduction in the expression of markers of bone metastasis, indicating that the epigenetic action of TETs is a prerequisite for IL-1β-dependent tumor progression and bone metastasis formation.
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spelling pubmed-97413322022-12-11 The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line Bellavia, Daniele Costa, Viviana De Luca, Angela Cordaro, Aurora Fini, Milena Giavaresi, Gianluca Caradonna, Fabio Raimondi, Lavinia Int J Mol Sci Article The existence of a tight relationship between inflammation and epigenetics that in primary breast tumor cells can lead to tumor progression and the formation of bone metastases was investigated. It was highlighted how the induction of tumor progression and bone metastasis by Interleukin-1 beta, in a non-metastatic breast cancer cell line, MCF-7, was dependent on the de-methylating actions of ten-eleven translocation proteins (TETs). In fact, the inhibition of their activity by the Bobcat339 molecule, an inhibitor of TET enzymes, determined on the one hand, the modulation of the epithelial-mesenchymal transition process, and on the other hand, the reduction in the expression of markers of bone metastasis, indicating that the epigenetic action of TETs is a prerequisite for IL-1β-dependent tumor progression and bone metastasis formation. MDPI 2022-12-06 /pmc/articles/PMC9741332/ /pubmed/36499741 http://dx.doi.org/10.3390/ijms232315422 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bellavia, Daniele
Costa, Viviana
De Luca, Angela
Cordaro, Aurora
Fini, Milena
Giavaresi, Gianluca
Caradonna, Fabio
Raimondi, Lavinia
The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title_full The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title_fullStr The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title_full_unstemmed The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title_short The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
title_sort binomial “inflammation-epigenetics” in breast cancer progression and bone metastasis: il-1β actions are influenced by tet inhibitor in mcf-7 cell line
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741332/
https://www.ncbi.nlm.nih.gov/pubmed/36499741
http://dx.doi.org/10.3390/ijms232315422
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