Targeted Protein Degradation: Clinical Advances in the Field of Oncology

The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality with the promise to tame disease-relevant proteins in ways that are difficult or impossible to tackle with other strategies. While we move into the third decade of TPD, multiple degrader drugs have entered t...

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Detalles Bibliográficos
Autores principales: Salama, Abdelrahman K. A. A., Trkulja, Marija V., Casanova, Emilio, Uras, Iris Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741350/
https://www.ncbi.nlm.nih.gov/pubmed/36499765
http://dx.doi.org/10.3390/ijms232315440
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author Salama, Abdelrahman K. A. A.
Trkulja, Marija V.
Casanova, Emilio
Uras, Iris Z.
author_facet Salama, Abdelrahman K. A. A.
Trkulja, Marija V.
Casanova, Emilio
Uras, Iris Z.
author_sort Salama, Abdelrahman K. A. A.
collection PubMed
description The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality with the promise to tame disease-relevant proteins in ways that are difficult or impossible to tackle with other strategies. While we move into the third decade of TPD, multiple degrader drugs have entered the stage of the clinic and many more are expected to follow. In this review, we provide an update on the most recent advances in the field of targeted degradation with insights into possible clinical implications for cancer prevention and treatment.
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spelling pubmed-97413502022-12-11 Targeted Protein Degradation: Clinical Advances in the Field of Oncology Salama, Abdelrahman K. A. A. Trkulja, Marija V. Casanova, Emilio Uras, Iris Z. Int J Mol Sci Review The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality with the promise to tame disease-relevant proteins in ways that are difficult or impossible to tackle with other strategies. While we move into the third decade of TPD, multiple degrader drugs have entered the stage of the clinic and many more are expected to follow. In this review, we provide an update on the most recent advances in the field of targeted degradation with insights into possible clinical implications for cancer prevention and treatment. MDPI 2022-12-06 /pmc/articles/PMC9741350/ /pubmed/36499765 http://dx.doi.org/10.3390/ijms232315440 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salama, Abdelrahman K. A. A.
Trkulja, Marija V.
Casanova, Emilio
Uras, Iris Z.
Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title_full Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title_fullStr Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title_full_unstemmed Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title_short Targeted Protein Degradation: Clinical Advances in the Field of Oncology
title_sort targeted protein degradation: clinical advances in the field of oncology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741350/
https://www.ncbi.nlm.nih.gov/pubmed/36499765
http://dx.doi.org/10.3390/ijms232315440
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