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Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies

Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed to evaluate whether subtle differences in LV diastolic function can be observed echocardiographically between young AR...

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Autores principales: Sciuk, Franziska, Vilsmaier, Theresa, Kramer, Marie, Langer, Magdalena, Kolbinger, Brenda, Li, Pengzhu, Jakob, André, Rogenhofer, Nina, Dalla-Pozza, Robert, Thaler, Christian, Haas, Nikolaus Alexander, Oberhoffer, Felix Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741392/
https://www.ncbi.nlm.nih.gov/pubmed/36498705
http://dx.doi.org/10.3390/jcm11237128
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author Sciuk, Franziska
Vilsmaier, Theresa
Kramer, Marie
Langer, Magdalena
Kolbinger, Brenda
Li, Pengzhu
Jakob, André
Rogenhofer, Nina
Dalla-Pozza, Robert
Thaler, Christian
Haas, Nikolaus Alexander
Oberhoffer, Felix Sebastian
author_facet Sciuk, Franziska
Vilsmaier, Theresa
Kramer, Marie
Langer, Magdalena
Kolbinger, Brenda
Li, Pengzhu
Jakob, André
Rogenhofer, Nina
Dalla-Pozza, Robert
Thaler, Christian
Haas, Nikolaus Alexander
Oberhoffer, Felix Sebastian
author_sort Sciuk, Franziska
collection PubMed
description Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed to evaluate whether subtle differences in LV diastolic function can be observed echocardiographically between young ART subjects and their spontaneously conceived peers. The echocardiographic assessment included the measurement of LV dimensions, mitral inflow velocities, and myocardial velocity at early diastole (E’, cm/s) at the LV wall and the interventricular septum (IVS). An average from E/E’LV and E/E’IVS (E/E’AVG) was derived. In total, 66 ART subjects and 83 controls (12.85 ± 5.80 years vs. 13.25 ± 5.89 years, p = 0.677) were included. The ART subjects demonstrated a significantly lower E’LV (19.29 ± 3.29 cm/s vs. 20.67 ± 3.78 cm/s, p = 0.020) compared to their spontaneously conceived peers. Study participants of ≥ 10 years of age displayed a significantly higher E/E’AVG (6.50 ± 0.97 vs. 6.05 ± 0.99, p = 0.035) within the ART cohort. The results of this study demonstrate a significantly lower LV diastolic function in the ART subjects. However, no significant changes in LV diastolic function were observed between the two groups when the results were adjusted for age, birth weight percentile, and gestational age. Those ART subjects born preterm might have an elevated risk of developing LV diastolic alterations and could therefore profit from close echocardiographic monitoring.
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spelling pubmed-97413922022-12-11 Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies Sciuk, Franziska Vilsmaier, Theresa Kramer, Marie Langer, Magdalena Kolbinger, Brenda Li, Pengzhu Jakob, André Rogenhofer, Nina Dalla-Pozza, Robert Thaler, Christian Haas, Nikolaus Alexander Oberhoffer, Felix Sebastian J Clin Med Article Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed to evaluate whether subtle differences in LV diastolic function can be observed echocardiographically between young ART subjects and their spontaneously conceived peers. The echocardiographic assessment included the measurement of LV dimensions, mitral inflow velocities, and myocardial velocity at early diastole (E’, cm/s) at the LV wall and the interventricular septum (IVS). An average from E/E’LV and E/E’IVS (E/E’AVG) was derived. In total, 66 ART subjects and 83 controls (12.85 ± 5.80 years vs. 13.25 ± 5.89 years, p = 0.677) were included. The ART subjects demonstrated a significantly lower E’LV (19.29 ± 3.29 cm/s vs. 20.67 ± 3.78 cm/s, p = 0.020) compared to their spontaneously conceived peers. Study participants of ≥ 10 years of age displayed a significantly higher E/E’AVG (6.50 ± 0.97 vs. 6.05 ± 0.99, p = 0.035) within the ART cohort. The results of this study demonstrate a significantly lower LV diastolic function in the ART subjects. However, no significant changes in LV diastolic function were observed between the two groups when the results were adjusted for age, birth weight percentile, and gestational age. Those ART subjects born preterm might have an elevated risk of developing LV diastolic alterations and could therefore profit from close echocardiographic monitoring. MDPI 2022-11-30 /pmc/articles/PMC9741392/ /pubmed/36498705 http://dx.doi.org/10.3390/jcm11237128 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sciuk, Franziska
Vilsmaier, Theresa
Kramer, Marie
Langer, Magdalena
Kolbinger, Brenda
Li, Pengzhu
Jakob, André
Rogenhofer, Nina
Dalla-Pozza, Robert
Thaler, Christian
Haas, Nikolaus Alexander
Oberhoffer, Felix Sebastian
Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title_full Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title_fullStr Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title_full_unstemmed Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title_short Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies
title_sort left ventricular diastolic function in subjects conceived through assisted reproductive technologies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741392/
https://www.ncbi.nlm.nih.gov/pubmed/36498705
http://dx.doi.org/10.3390/jcm11237128
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