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Plasma proteomic signature of decline in gait speed and grip strength
The biological mechanisms underlying decline in physical function with age remain unclear. We examined the plasma proteomic profile associated with longitudinal changes in physical function measured by gait speed and grip strength in community‐dwelling adults. We applied an aptamer‐based platform to...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741503/ https://www.ncbi.nlm.nih.gov/pubmed/36333824 http://dx.doi.org/10.1111/acel.13736 |
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author | Liu, Xiaojuan Pan, Stephanie Xanthakis, Vanessa Vasan, Ramachandran S. Psaty, Bruce M. Austin, Thomas R. Newman, Anne B. Sanders, Jason L. Wu, Chenkai Tracy, Russell P. Gerszten, Robert E. Odden, Michelle C. |
author_facet | Liu, Xiaojuan Pan, Stephanie Xanthakis, Vanessa Vasan, Ramachandran S. Psaty, Bruce M. Austin, Thomas R. Newman, Anne B. Sanders, Jason L. Wu, Chenkai Tracy, Russell P. Gerszten, Robert E. Odden, Michelle C. |
author_sort | Liu, Xiaojuan |
collection | PubMed |
description | The biological mechanisms underlying decline in physical function with age remain unclear. We examined the plasma proteomic profile associated with longitudinal changes in physical function measured by gait speed and grip strength in community‐dwelling adults. We applied an aptamer‐based platform to assay 1154 plasma proteins on 2854 participants (60% women, aged 76 years) in the Cardiovascular Health Study (CHS) in 1992–1993 and 1130 participants (55% women, aged 54 years) in the Framingham Offspring Study (FOS) in 1991–1995. Gait speed and grip strength were measured annually for 7 years in CHS and at cycles 7 (1998–2001) and 8 (2005–2008) in FOS. The associations of individual protein levels (log‐transformed and standardized) with longitudinal changes in gait speed and grip strength in two populations were examined separately by linear mixed‐effects models. Meta‐analyses were implemented using random‐effects models and corrected for multiple testing. We found that plasma levels of 14 and 18 proteins were associated with changes in gait speed and grip strength, respectively (corrected p < 0.05). The proteins most strongly associated with gait speed decline were GDF‐15 (Meta‐analytic p = 1.58 × 10(−15)), pleiotrophin (1.23 × 10(−9)), and TIMP‐1 (5.97 × 10(−8)). For grip strength decline, the strongest associations were for carbonic anhydrase III (1.09 × 10(−7)), CDON (2.38 × 10(−7)), and SMOC1 (7.47 × 10(−7)). Several statistically significant proteins are involved in the inflammatory responses or antagonism of activin by follistatin pathway. These novel proteomic biomarkers and pathways should be further explored as future mechanisms and targets for age‐related functional decline. |
format | Online Article Text |
id | pubmed-9741503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97415032022-12-12 Plasma proteomic signature of decline in gait speed and grip strength Liu, Xiaojuan Pan, Stephanie Xanthakis, Vanessa Vasan, Ramachandran S. Psaty, Bruce M. Austin, Thomas R. Newman, Anne B. Sanders, Jason L. Wu, Chenkai Tracy, Russell P. Gerszten, Robert E. Odden, Michelle C. Aging Cell Research Articles The biological mechanisms underlying decline in physical function with age remain unclear. We examined the plasma proteomic profile associated with longitudinal changes in physical function measured by gait speed and grip strength in community‐dwelling adults. We applied an aptamer‐based platform to assay 1154 plasma proteins on 2854 participants (60% women, aged 76 years) in the Cardiovascular Health Study (CHS) in 1992–1993 and 1130 participants (55% women, aged 54 years) in the Framingham Offspring Study (FOS) in 1991–1995. Gait speed and grip strength were measured annually for 7 years in CHS and at cycles 7 (1998–2001) and 8 (2005–2008) in FOS. The associations of individual protein levels (log‐transformed and standardized) with longitudinal changes in gait speed and grip strength in two populations were examined separately by linear mixed‐effects models. Meta‐analyses were implemented using random‐effects models and corrected for multiple testing. We found that plasma levels of 14 and 18 proteins were associated with changes in gait speed and grip strength, respectively (corrected p < 0.05). The proteins most strongly associated with gait speed decline were GDF‐15 (Meta‐analytic p = 1.58 × 10(−15)), pleiotrophin (1.23 × 10(−9)), and TIMP‐1 (5.97 × 10(−8)). For grip strength decline, the strongest associations were for carbonic anhydrase III (1.09 × 10(−7)), CDON (2.38 × 10(−7)), and SMOC1 (7.47 × 10(−7)). Several statistically significant proteins are involved in the inflammatory responses or antagonism of activin by follistatin pathway. These novel proteomic biomarkers and pathways should be further explored as future mechanisms and targets for age‐related functional decline. John Wiley and Sons Inc. 2022-11-04 2022-12 /pmc/articles/PMC9741503/ /pubmed/36333824 http://dx.doi.org/10.1111/acel.13736 Text en © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Liu, Xiaojuan Pan, Stephanie Xanthakis, Vanessa Vasan, Ramachandran S. Psaty, Bruce M. Austin, Thomas R. Newman, Anne B. Sanders, Jason L. Wu, Chenkai Tracy, Russell P. Gerszten, Robert E. Odden, Michelle C. Plasma proteomic signature of decline in gait speed and grip strength |
title | Plasma proteomic signature of decline in gait speed and grip strength |
title_full | Plasma proteomic signature of decline in gait speed and grip strength |
title_fullStr | Plasma proteomic signature of decline in gait speed and grip strength |
title_full_unstemmed | Plasma proteomic signature of decline in gait speed and grip strength |
title_short | Plasma proteomic signature of decline in gait speed and grip strength |
title_sort | plasma proteomic signature of decline in gait speed and grip strength |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741503/ https://www.ncbi.nlm.nih.gov/pubmed/36333824 http://dx.doi.org/10.1111/acel.13736 |
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