Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may alter dementia onset. Mixed results are emerging from prior observational studies. To address this complexity, we deploy a causal inference approach accounting for the competing risk of death in emulated clin...

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Detalles Bibliográficos
Autores principales: Charpignon, Marie-Laure, Vakulenko-Lagun, Bella, Zheng, Bang, Magdamo, Colin, Su, Bowen, Evans, Kyle, Rodriguez, Steve, Sokolov, Artem, Boswell, Sarah, Sheu, Yi-Han, Somai, Melek, Middleton, Lefkos, Hyman, Bradley T., Betensky, Rebecca A., Finkelstein, Stan N., Welsch, Roy E., Tzoulaki, Ioanna, Blacker, Deborah, Das, Sudeshna, Albers, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741618/
https://www.ncbi.nlm.nih.gov/pubmed/36496454
http://dx.doi.org/10.1038/s41467-022-35157-w

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