Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

Small multidrug resistance (SMR) transporters contribute to antibiotic resistance through proton-coupled efflux of toxic compounds. Previous biophysical studies of the E. coli SMR transporter EmrE suggest that it should also be able to perform proton/toxin symport or uniport, leading to toxin suscep...

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Detalles Bibliográficos
Autores principales: Spreacker, Peyton J., Thomas, Nathan E., Beeninga, Will F., Brousseau, Merissa, Porter, Colin J., Hibbs, Kylie M., Henzler-Wildman, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741644/
https://www.ncbi.nlm.nih.gov/pubmed/36496486
http://dx.doi.org/10.1038/s41467-022-35410-2

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