Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer

BACKGROUND: Excessive extracellular matrix (ECM) deposition in pancreatic ductal adenocarcinoma (PDAC) severely limits therapeutic drug penetration into tumors and is associated with poor prognosis. Collagen is the most abundant matrix protein in the tumor ECM, which is the main obstacle that severe...

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Detalles Bibliográficos
Autores principales: Yang, Xiao-Yan, Zhang, Jin-Guo, Zhou, Qiao-Mei, Yu, Jie-Ni, Lu, Yuan-Fei, Wang, Xiao-Jie, Zhou, Jia-Ping, Ding, Xin-Fa, Du, Yong-Zhong, Yu, Ri-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741808/
https://www.ncbi.nlm.nih.gov/pubmed/36496411
http://dx.doi.org/10.1186/s12951-022-01738-6

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