Cargando…

Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination

Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vacc...

Descripción completa

Detalles Bibliográficos
Autores principales: Arinola, Ganiyu Olatunbosun, Disu, Elizabeth, Babatunde, Adedokun, Olopade, Christopher, Olopade, Olufunmilayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742099/
https://www.ncbi.nlm.nih.gov/pubmed/36518602
http://dx.doi.org/10.1097/BS9.0000000000000115
_version_ 1784848460558630912
author Arinola, Ganiyu Olatunbosun
Disu, Elizabeth
Babatunde, Adedokun
Olopade, Christopher
Olopade, Olufunmilayo
author_facet Arinola, Ganiyu Olatunbosun
Disu, Elizabeth
Babatunde, Adedokun
Olopade, Christopher
Olopade, Olufunmilayo
author_sort Arinola, Ganiyu Olatunbosun
collection PubMed
description Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine. METHOD: The levels of humoral (innate and adaptive) immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD. Serum innate humoral immune factors [Complement factors (C1q and C4), transferrin, ferritin, and C-reactive protein (CRP)] and adaptive humoral immune factors [IgG, IgA, IgM, and IgE] were determined using ELISA. Nutritionally essential trace elements such as iron (Fe), copper (Cu), and zinc (Zn) were measured also using an atomic absorption spectrophotometer. RESULTS: The serum levels of certain innate humoral immune factors (ferritin, CRP, and C4), only one adaptive humoral immune factors (IgE), and essential trace elements (Fe, Zn, and Cu) were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels. CONCLUSION: Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors. This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD.
format Online
Article
Text
id pubmed-9742099
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-97420992022-12-13 Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination Arinola, Ganiyu Olatunbosun Disu, Elizabeth Babatunde, Adedokun Olopade, Christopher Olopade, Olufunmilayo Blood Sci Research Article Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine. METHOD: The levels of humoral (innate and adaptive) immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD. Serum innate humoral immune factors [Complement factors (C1q and C4), transferrin, ferritin, and C-reactive protein (CRP)] and adaptive humoral immune factors [IgG, IgA, IgM, and IgE] were determined using ELISA. Nutritionally essential trace elements such as iron (Fe), copper (Cu), and zinc (Zn) were measured also using an atomic absorption spectrophotometer. RESULTS: The serum levels of certain innate humoral immune factors (ferritin, CRP, and C4), only one adaptive humoral immune factors (IgE), and essential trace elements (Fe, Zn, and Cu) were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels. CONCLUSION: Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors. This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD. Lippincott Williams & Wilkins 2022-07-06 /pmc/articles/PMC9742099/ /pubmed/36518602 http://dx.doi.org/10.1097/BS9.0000000000000115 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS). https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Arinola, Ganiyu Olatunbosun
Disu, Elizabeth
Babatunde, Adedokun
Olopade, Christopher
Olopade, Olufunmilayo
Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title_full Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title_fullStr Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title_full_unstemmed Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title_short Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination
title_sort assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease nigerian children before and after prevenar 13 pneumococcal vaccination
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742099/
https://www.ncbi.nlm.nih.gov/pubmed/36518602
http://dx.doi.org/10.1097/BS9.0000000000000115
work_keys_str_mv AT arinolaganiyuolatunbosun assessmentofhumoralimmunityandnutritionallyessentialtraceelementsinsteadystatesicklecelldiseasenigerianchildrenbeforeandafterprevenar13pneumococcalvaccination
AT disuelizabeth assessmentofhumoralimmunityandnutritionallyessentialtraceelementsinsteadystatesicklecelldiseasenigerianchildrenbeforeandafterprevenar13pneumococcalvaccination
AT babatundeadedokun assessmentofhumoralimmunityandnutritionallyessentialtraceelementsinsteadystatesicklecelldiseasenigerianchildrenbeforeandafterprevenar13pneumococcalvaccination
AT olopadechristopher assessmentofhumoralimmunityandnutritionallyessentialtraceelementsinsteadystatesicklecelldiseasenigerianchildrenbeforeandafterprevenar13pneumococcalvaccination
AT olopadeolufunmilayo assessmentofhumoralimmunityandnutritionallyessentialtraceelementsinsteadystatesicklecelldiseasenigerianchildrenbeforeandafterprevenar13pneumococcalvaccination