RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia

N(6)-Methyladenosine (m(6)A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m(6)A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m(6)A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m(6)A biology by focusing on writers, readers, and erasers of m(6)A modification, and describe the development of high-throughput methods for RNA m(6)A mapping. We further discuss the important roles of m(6)A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m(6)A modifiers. Overall, this review provides a comprehensive summary of RNA m(6)A biology in acute myeloid leukemia.