RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia

N(6)-Methyladenosine (m(6)A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m(6)A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The cur...

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Autores principales: Yin, Rong, Li, Yashu, Tian, Wen, Zhou, Fuling, Zhang, Haojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Special Issue: RNA and Hematopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742108/
https://www.ncbi.nlm.nih.gov/pubmed/36518594
http://dx.doi.org/10.1097/BS9.0000000000000131
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author Yin, Rong
Li, Yashu
Tian, Wen
Zhou, Fuling
Zhang, Haojian
author_facet Yin, Rong
Li, Yashu
Tian, Wen
Zhou, Fuling
Zhang, Haojian
author_sort Yin, Rong
collection PubMed
description N(6)-Methyladenosine (m(6)A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m(6)A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m(6)A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m(6)A biology by focusing on writers, readers, and erasers of m(6)A modification, and describe the development of high-throughput methods for RNA m(6)A mapping. We further discuss the important roles of m(6)A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m(6)A modifiers. Overall, this review provides a comprehensive summary of RNA m(6)A biology in acute myeloid leukemia.
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spelling pubmed-97421082022-12-13 RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia Yin, Rong Li, Yashu Tian, Wen Zhou, Fuling Zhang, Haojian Blood Sci Special Issue: RNA and Hematopoiesis N(6)-Methyladenosine (m(6)A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m(6)A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m(6)A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m(6)A biology by focusing on writers, readers, and erasers of m(6)A modification, and describe the development of high-throughput methods for RNA m(6)A mapping. We further discuss the important roles of m(6)A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m(6)A modifiers. Overall, this review provides a comprehensive summary of RNA m(6)A biology in acute myeloid leukemia. Lippincott Williams & Wilkins 2022-07-20 /pmc/articles/PMC9742108/ /pubmed/36518594 http://dx.doi.org/10.1097/BS9.0000000000000131 Text en Copyright © 2022 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Medical Association (CMA) and Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College (IHCAMS). https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue: RNA and Hematopoiesis
Yin, Rong
Li, Yashu
Tian, Wen
Zhou, Fuling
Zhang, Haojian
RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title_full RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title_fullStr RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title_full_unstemmed RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title_short RNA m(6)A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia
title_sort rna m(6)a modification: mapping methods, roles, and mechanisms in acute myeloid leukemia
topic Special Issue: RNA and Hematopoiesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742108/
https://www.ncbi.nlm.nih.gov/pubmed/36518594
http://dx.doi.org/10.1097/BS9.0000000000000131
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