SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

Natural killer (NK) cells are cytotoxic effector cells that target and lyse virally infected cells; many viruses therefore encode mechanisms to escape such NK cell killing. Here, we interrogate the ability of SARS-CoV-2 to modulate NK cell recognition and lysis of infected cells. We find that NK cel...

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Detalles Bibliográficos
Autores principales: Lee, Madeline J., Leong, Michelle W., Rustagi, Arjun, Beck, Aimee, Zeng, Leiping, Holmes, Susan, Qi, Lei S., Blish, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742201/
https://www.ncbi.nlm.nih.gov/pubmed/36543165
http://dx.doi.org/10.1016/j.celrep.2022.111892

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