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Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)

Baccharis dracunculifolia DC (Lamiaceae) (Asteraceae) is found in South America, mainly in Argentina, Brazil, Bolivia, Paraguay and Uruguay. Folk medicine is used as a sedative, hypotensive, bronchodilator, cardiovascular disorders, anti-flu, and also in skin wounds. Considered the main source of gr...

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Autores principales: Gazim, Zilda Cristiani, Valle, Juliana Silveira, Carvalho dos Santos, Isabela, Rahal, Isabelle Luiz, Silva, Gabriela Catuzo Canonico, Lopes, Ana Daniela, Ruiz, Suelen Pereira, Faria, Maria Graciela Iecher, Piau Junior, Ranulfo, Gonçalves, Daniela Dib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742423/
https://www.ncbi.nlm.nih.gov/pubmed/36518668
http://dx.doi.org/10.3389/fphar.2022.1048688
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author Gazim, Zilda Cristiani
Valle, Juliana Silveira
Carvalho dos Santos, Isabela
Rahal, Isabelle Luiz
Silva, Gabriela Catuzo Canonico
Lopes, Ana Daniela
Ruiz, Suelen Pereira
Faria, Maria Graciela Iecher
Piau Junior, Ranulfo
Gonçalves, Daniela Dib
author_facet Gazim, Zilda Cristiani
Valle, Juliana Silveira
Carvalho dos Santos, Isabela
Rahal, Isabelle Luiz
Silva, Gabriela Catuzo Canonico
Lopes, Ana Daniela
Ruiz, Suelen Pereira
Faria, Maria Graciela Iecher
Piau Junior, Ranulfo
Gonçalves, Daniela Dib
author_sort Gazim, Zilda Cristiani
collection PubMed
description Baccharis dracunculifolia DC (Lamiaceae) (Asteraceae) is found in South America, mainly in Argentina, Brazil, Bolivia, Paraguay and Uruguay. Folk medicine is used as a sedative, hypotensive, bronchodilator, cardiovascular disorders, anti-flu, and also in skin wounds. Considered the main source of green propolis, which increases the pharmacological interest in this species. It is also known as a “benefactor” plant facilitating the development of other plant species around it, being indicated for the recovery of degraded areas. This species has been studied for decades in order to isolate and identify the active principles present in the aerial parts (leaves and flowers) and roots. The present study consists of a review of the scientific literature addressing the ethnobotanical, ethnomedicinal, phytochemical, pharmacological and potential cytotoxic effects of the B. dracunculifolia species. In this survey, we sought to investigate issues related to the botanical and geographic description of the species, the ethnobotanical uses, as well as the phytochemical studies of the essential oil, extracts and green propolis obtained from the aerial parts and roots of B. dracunculifolia. Using high precision analytical tools, numerous compounds have already been isolated and identified from leaves and flowers such as the flavonoids: naringenin, acacetin, dihydrokaempferol, isosakuranetin and kaempferide; phenolic acids: p-coumaric, dihydrocoumaric, ferulic (E)-cinnamic, hydroxycinnamic, gallic, caffeic, and several caffeoylquinic acids derivatives; phenolic acids prenylated: artepillin C, baccharin, drupanin; the glycosides dracuculifosides and the pentacyclic triterpenoids: Baccharis oxide and friedelanol. The predominant class in the essential oil of leaves and flowers are terpenoids comprising oxygenated monoterpenes and sesquiterpenes, highlighting the compounds nerolidol, spathulenol, germacrene D and bicyclogermacrene. These compounds give the species high antimicrobial, antioxidant, antitumor, analgesic, immunomodulatory and antiparasitic potential, making this species a promising herbal medicine. In vitro toxicity assays with B. dracunculifolia extract showed low or no cytotoxicity. However, in vivo analyses with high doses of the aqueous extract resulted in genotoxic effects, which leads us to conclude that the toxicity of this plant is dose-dependent.
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spelling pubmed-97424232022-12-13 Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE) Gazim, Zilda Cristiani Valle, Juliana Silveira Carvalho dos Santos, Isabela Rahal, Isabelle Luiz Silva, Gabriela Catuzo Canonico Lopes, Ana Daniela Ruiz, Suelen Pereira Faria, Maria Graciela Iecher Piau Junior, Ranulfo Gonçalves, Daniela Dib Front Pharmacol Pharmacology Baccharis dracunculifolia DC (Lamiaceae) (Asteraceae) is found in South America, mainly in Argentina, Brazil, Bolivia, Paraguay and Uruguay. Folk medicine is used as a sedative, hypotensive, bronchodilator, cardiovascular disorders, anti-flu, and also in skin wounds. Considered the main source of green propolis, which increases the pharmacological interest in this species. It is also known as a “benefactor” plant facilitating the development of other plant species around it, being indicated for the recovery of degraded areas. This species has been studied for decades in order to isolate and identify the active principles present in the aerial parts (leaves and flowers) and roots. The present study consists of a review of the scientific literature addressing the ethnobotanical, ethnomedicinal, phytochemical, pharmacological and potential cytotoxic effects of the B. dracunculifolia species. In this survey, we sought to investigate issues related to the botanical and geographic description of the species, the ethnobotanical uses, as well as the phytochemical studies of the essential oil, extracts and green propolis obtained from the aerial parts and roots of B. dracunculifolia. Using high precision analytical tools, numerous compounds have already been isolated and identified from leaves and flowers such as the flavonoids: naringenin, acacetin, dihydrokaempferol, isosakuranetin and kaempferide; phenolic acids: p-coumaric, dihydrocoumaric, ferulic (E)-cinnamic, hydroxycinnamic, gallic, caffeic, and several caffeoylquinic acids derivatives; phenolic acids prenylated: artepillin C, baccharin, drupanin; the glycosides dracuculifosides and the pentacyclic triterpenoids: Baccharis oxide and friedelanol. The predominant class in the essential oil of leaves and flowers are terpenoids comprising oxygenated monoterpenes and sesquiterpenes, highlighting the compounds nerolidol, spathulenol, germacrene D and bicyclogermacrene. These compounds give the species high antimicrobial, antioxidant, antitumor, analgesic, immunomodulatory and antiparasitic potential, making this species a promising herbal medicine. In vitro toxicity assays with B. dracunculifolia extract showed low or no cytotoxicity. However, in vivo analyses with high doses of the aqueous extract resulted in genotoxic effects, which leads us to conclude that the toxicity of this plant is dose-dependent. Frontiers Media S.A. 2022-11-28 /pmc/articles/PMC9742423/ /pubmed/36518668 http://dx.doi.org/10.3389/fphar.2022.1048688 Text en Copyright © 2022 Gazim, Valle, Carvalho dos Santos, Rahal, Silva, Lopes, Ruiz, Faria, Piau Junior and Gonçalves. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gazim, Zilda Cristiani
Valle, Juliana Silveira
Carvalho dos Santos, Isabela
Rahal, Isabelle Luiz
Silva, Gabriela Catuzo Canonico
Lopes, Ana Daniela
Ruiz, Suelen Pereira
Faria, Maria Graciela Iecher
Piau Junior, Ranulfo
Gonçalves, Daniela Dib
Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title_full Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title_fullStr Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title_full_unstemmed Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title_short Ethnomedicinal, phytochemical and pharmacological investigations of Baccharis dracunculifolia DC. (ASTERACEAE)
title_sort ethnomedicinal, phytochemical and pharmacological investigations of baccharis dracunculifolia dc. (asteraceae)
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742423/
https://www.ncbi.nlm.nih.gov/pubmed/36518668
http://dx.doi.org/10.3389/fphar.2022.1048688
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