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Baseline immune signature score of Tregs × HLA-DR(+)CD4(+) T cells × PD1(+)CD8(+) T cells predicts outcome to immunotherapy in cancer patients
BACKGROUND: The use of immunotherapy (IT) is rapidly increasing across different tumor entities. PD-L1 expression is primarily used for therapy evaluation. The disadvantages of PD-L1 status are spatial and temporal heterogeneity as well as tumor type-dependent variation of predictive value. To optim...
Autores principales: | Mispelbaum, Rebekka, Hattenhauer, Sandra Tessa, Held, Stefanie Andrea Erika, Brossart, Peter, Heine, Annkristin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742462/ https://www.ncbi.nlm.nih.gov/pubmed/36518753 http://dx.doi.org/10.3389/fimmu.2022.1054161 |
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