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Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated

Experimental autoimmune encephalomyelitis (EAE) can be induced in many animal strains by inoculation with central nervous system antigens and adjuvant or by the passive transfer of lymphocytes reactive with these antigens and is widely used as an animal model for multiple sclerosis (MS). There are r...

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Autores principales: McCombe, Pamela A., Greer, Judith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742606/
https://www.ncbi.nlm.nih.gov/pubmed/36518769
http://dx.doi.org/10.3389/fimmu.2022.1059833
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author McCombe, Pamela A.
Greer, Judith M.
author_facet McCombe, Pamela A.
Greer, Judith M.
author_sort McCombe, Pamela A.
collection PubMed
description Experimental autoimmune encephalomyelitis (EAE) can be induced in many animal strains by inoculation with central nervous system antigens and adjuvant or by the passive transfer of lymphocytes reactive with these antigens and is widely used as an animal model for multiple sclerosis (MS). There are reports that female sex and pregnancy affect EAE. Here we review the effects of biological sex and the effects of pregnancy on the clinical features (including disease susceptibility) and pathophysiology of EAE. We also review reports of the possible mechanisms underlying these differences. These include sex-related differences in the immune system and in the central nervous system, the effects of hormones and the sex chromosomes and molecules unique to pregnancy. We also review sex differences in the response to factors that can modify the course of EAE. Our conclusion is that the effects of biological sex in EAE vary amongst animal models and should not be widely extrapolated. In EAE, it is therefore essential that studies looking at the effects of biological sex or pregnancy give full information about the model that is used (i.e. animal strain, sex, the inducing antigen, timing of EAE induction in relation to pregnancy, etc.). In addition, it would be preferable if more than one EAE model were used, to show if any observed effects are generalizable. This is clearly a field that requires further work. However, understanding of the mechanisms of sex differences could lead to greater understanding of EAE, and suggest possible therapies for MS.
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spelling pubmed-97426062022-12-13 Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated McCombe, Pamela A. Greer, Judith M. Front Immunol Immunology Experimental autoimmune encephalomyelitis (EAE) can be induced in many animal strains by inoculation with central nervous system antigens and adjuvant or by the passive transfer of lymphocytes reactive with these antigens and is widely used as an animal model for multiple sclerosis (MS). There are reports that female sex and pregnancy affect EAE. Here we review the effects of biological sex and the effects of pregnancy on the clinical features (including disease susceptibility) and pathophysiology of EAE. We also review reports of the possible mechanisms underlying these differences. These include sex-related differences in the immune system and in the central nervous system, the effects of hormones and the sex chromosomes and molecules unique to pregnancy. We also review sex differences in the response to factors that can modify the course of EAE. Our conclusion is that the effects of biological sex in EAE vary amongst animal models and should not be widely extrapolated. In EAE, it is therefore essential that studies looking at the effects of biological sex or pregnancy give full information about the model that is used (i.e. animal strain, sex, the inducing antigen, timing of EAE induction in relation to pregnancy, etc.). In addition, it would be preferable if more than one EAE model were used, to show if any observed effects are generalizable. This is clearly a field that requires further work. However, understanding of the mechanisms of sex differences could lead to greater understanding of EAE, and suggest possible therapies for MS. Frontiers Media S.A. 2022-11-28 /pmc/articles/PMC9742606/ /pubmed/36518769 http://dx.doi.org/10.3389/fimmu.2022.1059833 Text en Copyright © 2022 McCombe and Greer https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
McCombe, Pamela A.
Greer, Judith M.
Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title_full Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title_fullStr Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title_full_unstemmed Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title_short Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
title_sort effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: it’s complicated
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742606/
https://www.ncbi.nlm.nih.gov/pubmed/36518769
http://dx.doi.org/10.3389/fimmu.2022.1059833
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