Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model

The pathophysiology underlying the loss of dopaminergic neurons in Parkinson’s disease (PD) is unclear. A gap of knowledge in the molecular and cellular events leading to degeneration of the nigrostriatal DA system is a major barrier to the development of effective therapies for PD. 1-methyl-4-pheny...

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Detalles Bibliográficos
Autores principales: Cuevas, Elvis, Guzman, Aida, Burks, Susan M., Ramirez-Lee, Alejandro, Ali, Syed F., Imam, Syed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742814/
https://www.ncbi.nlm.nih.gov/pubmed/36518412
http://dx.doi.org/10.1016/j.toxrep.2022.03.047

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