Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action

Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples with highly degraded RNA pose a particularly difficu...

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Detalles Bibliográficos
Autores principales: Cannizzo, Michael D., Wood, Charles E., Hester, Susan D., Wehmas, Leah C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742836/
https://www.ncbi.nlm.nih.gov/pubmed/36518475
http://dx.doi.org/10.1016/j.toxrep.2022.04.012

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