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Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study

STUDY OBJECTIVES: We investigated associations between inflammatory profiles/clusters and sleep measures in people living with HIV and demographically-/lifestyle-similar HIV-negative controls in the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY)-Sleep substudy. METHODS: Prima...

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Autores principales: Bakewell, Nicholas, Sabin, Caroline A, Negi, Riya, Garcia-Leon, Alejandro, Winston, Alan, Sachikonye, Memory, Doyle, Nicki, Redline, Susan, Mallon, Patrick W G, Kunisaki, Ken M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742892/
https://www.ncbi.nlm.nih.gov/pubmed/36104003
http://dx.doi.org/10.1093/sleep/zsac212
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author Bakewell, Nicholas
Sabin, Caroline A
Negi, Riya
Garcia-Leon, Alejandro
Winston, Alan
Sachikonye, Memory
Doyle, Nicki
Redline, Susan
Mallon, Patrick W G
Kunisaki, Ken M
author_facet Bakewell, Nicholas
Sabin, Caroline A
Negi, Riya
Garcia-Leon, Alejandro
Winston, Alan
Sachikonye, Memory
Doyle, Nicki
Redline, Susan
Mallon, Patrick W G
Kunisaki, Ken M
author_sort Bakewell, Nicholas
collection PubMed
description STUDY OBJECTIVES: We investigated associations between inflammatory profiles/clusters and sleep measures in people living with HIV and demographically-/lifestyle-similar HIV-negative controls in the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY)-Sleep substudy. METHODS: Primary outcome was insomnia (Insomnia Severity Index [ISI]>15). Secondary sleep outcomes included 7-day actigraphy (e.g. mean/standard deviation of sleep duration/efficiency), overnight oximetry (e.g. oxygen desaturation index [ODI]) and patient-reported measures (Patient-Reported Outcomes Measurement Information System (PROMIS) sleep questionnaires). Participants were grouped using Principal Component Analysis of 31 biomarkers across several inflammatory pathways followed by cluster analysis. Between-cluster differences in baseline characteristics and sleep outcomes were assessed using Kruskal–Wallis/logistic regression/Chi-squared/Fisher’s exact tests. RESULTS: Of the 465 participants included (74% people with HIV, median [interquartile range] age 54 [50–60] years), only 18% had insomnia and secondary sleep outcomes suggested generally good sleep (e.g. ODI 3.1/hr [1.5–6.4]). Three clusters with distinct inflammatory profiles were identified: “gut/immune activation” (n = 47), “neurovascular” (n = 209), and “reference” (relatively lower inflammation; n = 209). The “neurovascular” cluster included higher proportions of people with HIV, obesity (BMI>30 kg/m(2)), and previous cardiovascular disease, mental health disorder, and arthritis of knee/hip relative to the other two clusters. No clinically relevant between-cluster differences were observed in proportions with insomnia (17%, 18%, 20%) before (p = .76) or after (p = .75) adjustment for potential confounders. Few associations were observed among actigraphy, oximetry, and PROMIS measures. CONCLUSIONS: Although associations could exist with other sleep measures or biomarker types not assessed, our findings do not support a strong association between sleep and inflammation in people with HIV.
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spelling pubmed-97428922022-12-13 Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study Bakewell, Nicholas Sabin, Caroline A Negi, Riya Garcia-Leon, Alejandro Winston, Alan Sachikonye, Memory Doyle, Nicki Redline, Susan Mallon, Patrick W G Kunisaki, Ken M Sleep Sleep, Health, and Disease STUDY OBJECTIVES: We investigated associations between inflammatory profiles/clusters and sleep measures in people living with HIV and demographically-/lifestyle-similar HIV-negative controls in the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY)-Sleep substudy. METHODS: Primary outcome was insomnia (Insomnia Severity Index [ISI]>15). Secondary sleep outcomes included 7-day actigraphy (e.g. mean/standard deviation of sleep duration/efficiency), overnight oximetry (e.g. oxygen desaturation index [ODI]) and patient-reported measures (Patient-Reported Outcomes Measurement Information System (PROMIS) sleep questionnaires). Participants were grouped using Principal Component Analysis of 31 biomarkers across several inflammatory pathways followed by cluster analysis. Between-cluster differences in baseline characteristics and sleep outcomes were assessed using Kruskal–Wallis/logistic regression/Chi-squared/Fisher’s exact tests. RESULTS: Of the 465 participants included (74% people with HIV, median [interquartile range] age 54 [50–60] years), only 18% had insomnia and secondary sleep outcomes suggested generally good sleep (e.g. ODI 3.1/hr [1.5–6.4]). Three clusters with distinct inflammatory profiles were identified: “gut/immune activation” (n = 47), “neurovascular” (n = 209), and “reference” (relatively lower inflammation; n = 209). The “neurovascular” cluster included higher proportions of people with HIV, obesity (BMI>30 kg/m(2)), and previous cardiovascular disease, mental health disorder, and arthritis of knee/hip relative to the other two clusters. No clinically relevant between-cluster differences were observed in proportions with insomnia (17%, 18%, 20%) before (p = .76) or after (p = .75) adjustment for potential confounders. Few associations were observed among actigraphy, oximetry, and PROMIS measures. CONCLUSIONS: Although associations could exist with other sleep measures or biomarker types not assessed, our findings do not support a strong association between sleep and inflammation in people with HIV. Oxford University Press 2022-09-14 /pmc/articles/PMC9742892/ /pubmed/36104003 http://dx.doi.org/10.1093/sleep/zsac212 Text en © Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Sleep, Health, and Disease
Bakewell, Nicholas
Sabin, Caroline A
Negi, Riya
Garcia-Leon, Alejandro
Winston, Alan
Sachikonye, Memory
Doyle, Nicki
Redline, Susan
Mallon, Patrick W G
Kunisaki, Ken M
Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title_full Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title_fullStr Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title_full_unstemmed Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title_short Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study
title_sort biomarker associations with insomnia and secondary sleep outcomes in persons with and without hiv in the poppy-sleep substudy: a cohort study
topic Sleep, Health, and Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742892/
https://www.ncbi.nlm.nih.gov/pubmed/36104003
http://dx.doi.org/10.1093/sleep/zsac212
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