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Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient
Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742931/ https://www.ncbi.nlm.nih.gov/pubmed/36484293 http://dx.doi.org/10.1177/15579883221139914 |
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author | Mrabet, Sanda Romdhane, Wiem Fradi, Asma Boukadida, Raja Azzabi, Awatef Guedri, Yosra Sahtout, Wissal BenAicha, Narjess Abdessayed, Nihed Mokni, Moncef Zellama, Dorsaf Achour, Abdellatif |
author_facet | Mrabet, Sanda Romdhane, Wiem Fradi, Asma Boukadida, Raja Azzabi, Awatef Guedri, Yosra Sahtout, Wissal BenAicha, Narjess Abdessayed, Nihed Mokni, Moncef Zellama, Dorsaf Achour, Abdellatif |
author_sort | Mrabet, Sanda |
collection | PubMed |
description | Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a polyparasitic infection (Giardia lamblia, Entamoeba coli, and Endolimax nana) resulting in a severe biopsy-proven AIN in a 61-year-old male patient. Despite the antiparasitic treatment followed by corticosteroid therapy, and during the 6-month follow-up period, the patient remained dialysis-dependent, and he developed autoimmune hemolytic anemia. Extensive search for another infection or neoplasia was negative. Immunological tests were also negative. The resulting hypersensitivity reaction to the triple parasite infection would have led to fatal evolution for the kidneys affected by this unusual type of AIN. |
format | Online Article Text |
id | pubmed-9742931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-97429312022-12-13 Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient Mrabet, Sanda Romdhane, Wiem Fradi, Asma Boukadida, Raja Azzabi, Awatef Guedri, Yosra Sahtout, Wissal BenAicha, Narjess Abdessayed, Nihed Mokni, Moncef Zellama, Dorsaf Achour, Abdellatif Am J Mens Health Case Report Acute interstitial nephritis (AIN) is a relevant cause of acute renal failure. Drugs are the predominant cause, followed by infections and idiopathic lesions. AIN, as a form of hypersensitivity reaction, is an uncommon manifestation in the setting of human parasitic infections. We report a case of a polyparasitic infection (Giardia lamblia, Entamoeba coli, and Endolimax nana) resulting in a severe biopsy-proven AIN in a 61-year-old male patient. Despite the antiparasitic treatment followed by corticosteroid therapy, and during the 6-month follow-up period, the patient remained dialysis-dependent, and he developed autoimmune hemolytic anemia. Extensive search for another infection or neoplasia was negative. Immunological tests were also negative. The resulting hypersensitivity reaction to the triple parasite infection would have led to fatal evolution for the kidneys affected by this unusual type of AIN. SAGE Publications 2022-12-09 /pmc/articles/PMC9742931/ /pubmed/36484293 http://dx.doi.org/10.1177/15579883221139914 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Mrabet, Sanda Romdhane, Wiem Fradi, Asma Boukadida, Raja Azzabi, Awatef Guedri, Yosra Sahtout, Wissal BenAicha, Narjess Abdessayed, Nihed Mokni, Moncef Zellama, Dorsaf Achour, Abdellatif Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia due to Polyparasitic Infection in an Immunocompetent Male Patient |
title | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia
due to Polyparasitic Infection in an Immunocompetent Male
Patient |
title_full | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia
due to Polyparasitic Infection in an Immunocompetent Male
Patient |
title_fullStr | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia
due to Polyparasitic Infection in an Immunocompetent Male
Patient |
title_full_unstemmed | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia
due to Polyparasitic Infection in an Immunocompetent Male
Patient |
title_short | Severe Acute Interstitial Nephritis, Dermatitis, and Hemolytic Anemia
due to Polyparasitic Infection in an Immunocompetent Male
Patient |
title_sort | severe acute interstitial nephritis, dermatitis, and hemolytic anemia
due to polyparasitic infection in an immunocompetent male
patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742931/ https://www.ncbi.nlm.nih.gov/pubmed/36484293 http://dx.doi.org/10.1177/15579883221139914 |
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