Cargando…

In vitro and in vivo hepatotoxicity study of Afriplex™ GRT through an inflammatory response

BACKGROUND: The focus on traditional and complementary medicine for supplementation and treatment of diseases is high. Aspalathus linearis commonly known as Rooibos showed several beneficial effects, this led to the standardized production of a pharmaceutical grade green rooibos extract (Afriplex TM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gabuza, Kwazikwakhe B., Buthelezi, Ntandoyenkosi, Kappo, Abidemi Paul, Mabuda, Thendo I., Mosa, Rebamang, Louw, Johan, Muller, Christo J.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742939/ https://www.ncbi.nlm.nih.gov/pubmed/36518449 http://dx.doi.org/10.1016/j.toxrep.2022.10.006

Ejemplares similares

An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage
por: Johnson, Rabia, et al.
Publicado: (2019)

Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling
por: Johnson, Rabia, et al.
Publicado: (2017)

Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2020)

Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
por: Kobayashi, Kenichi, et al.
Publicado: (2009)

Clinical Implications of TiGRT Algorithm for External Audit in Radiation Oncology
por: Shahbazi-Gahrouei, Daryoush, et al.
Publicado: (2017)

Comparative analyses and structural insights of the novel cytochrome P450 fusion protein family CYP5619 in Oomycetes
por: Bamal, Hans Denis, et al.
Publicado: (2018)

Modulatory Effect of Methanol Extract of Piper guineense in CCl(4)-Induced Hepatotoxicity in Male Rats
por: Oyinloye, Babatunji Emmanuel, et al.
Publicado: (2017)

Molecular basis of the anti-hyperglycemic activity of RA-3 in hyperlipidemic and streptozotocin-induced type 2 diabetes in rats
por: Mabhida, Sihle Ephraim, et al.
Publicado: (2019)

Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats
por: Oyinloye, Babatunji Emmanuel, et al.
Publicado: (2016)

Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
por: Gabuza, Kwazikwakhe Bethuel, et al.
Publicado: (2020)

Correction to: A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats
por: Mabhida, Sihle Ephraim, et al.
Publicado: (2018)

A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats
por: Ephraim, Mabhida Sihle, et al.
Publicado: (2018)

Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
por: Ziqubu, Khanyisani, et al.
Publicado: (2020)

Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2017)

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2017)

Rooibos Flavonoids, Aspalathin, Isoorientin, and Orientin Ameliorate Antimycin A-Induced Mitochondrial Dysfunction by Improving Mitochondrial Bioenergetics in Cultured Skeletal Muscle Cells
por: Mthembu, Sinenhlanhla X. H., et al.
Publicado: (2021)

Parasite Survival and Disease Persistence in Cystic Fibrosis, Schistosomiasis and Pathogenic Bacterial Diseases: A Role for Universal Stress Proteins?
por: Masamba, Priscilla, et al.
Publicado: (2021)

Immunological and Biochemical Interplay between Cytokines, Oxidative Stress and Schistosomiasis
por: Masamba, Priscilla, et al.
Publicado: (2021)

Quercetin attenuated the Benzene-induced hemato- and hepatotoxicity in mice
por: Golabi-Habashi, Nayyer, et al.
Publicado: (2021)

Reactive Oxygen Species, Apoptosis, Antimicrobial Peptides and Human Inflammatory Diseases
por: Oyinloye, Babatunji Emmanuel, et al.
Publicado: (2015)

In Vivo Antihyperglycemic Activity of a Lanosteryl Triterpene from Protorhus longifolia
por: Mosa, Rebamang A., et al.
Publicado: (2015)

A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2018)

Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer
por: Ikwegbue, Paul Chukwudi, et al.
Publicado: (2017)

Closing the Gap: An Atomistic Structural and Functional Perspective of S. mansoni Universal Stress G4LZI3 Protein in Complex with Phenolic Compounds
por: Masamba, Priscilla, et al.
Publicado: (2021)

Hepatotoxic effects of silver nanoparticles on Clarias gariepinus; Biochemical, histopathological, and histochemical studies
por: Naguib, Mervat, et al.
Publicado: (2020)

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts
por: Oketch-Rabah, Hellen A., et al.
Publicado: (2020)

Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys
por: Orlando, Patrick, et al.
Publicado: (2019)

Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats
por: Patel, Oelfah, et al.
Publicado: (2019)

In vivo anti-hyperlipidemic activity of the triterpene from the stem bark of Protorhus longifolia (Benrh) Engl
por: Machaba, Kgothatso E, et al.
Publicado: (2014)

Mutation of a Major Keratin Phosphorylation Site Predisposes to Hepatotoxic Injury in Transgenic Mice
por: Ku, Nam-On, et al.
Publicado: (1998)

Proteins as Targets in Anti-Schistosomal Drug Discovery and Vaccine Development
por: Qokoyi, Ndibonani Kebonang, et al.
Publicado: (2021)

Bioorganometallic Compounds as Novel Drug Targets against Schistosomiasis in Sub-Saharan Africa: An alternative to Praziquantel?
por: Ndamse, Cuma Cumisa, et al.
Publicado: (2022)

Metabolomics and Chemoinformatics in Agricultural Biotechnology Research: Complementary Probes in Unravelling New Metabolites for Crop Improvement
por: Mashabela, Manamele Dannies, et al.
Publicado: (2022)

Applications of Metabolomics for the Elucidation of Abiotic Stress Tolerance in Plants: A Special Focus on Osmotic Stress and Heavy Metal Toxicity
por: Mashabela, Manamele Dannies, et al.
Publicado: (2023)

GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults
por: Palmer, Christine D., et al.
Publicado: (2023)

Antioxidant, anti-inflammatory and hepatoprotective activities of Terminalia bellirica and its bioactive component ellagic acid against diclofenac induced oxidative stress and hepatotoxicity
por: Gupta, Ashutosh, et al.
Publicado: (2020)

Maternal Gestational Dietary Fat has Minimal Effects on Serum Lipid Profiles and Hepatic Glucose Transporter 2 and No Effect on Glucokinase Expression in Neonatal Wistar Rat Offspring
por: Cerf, Marlon E., et al.
Publicado: (2011)

Drug-Induced Liver Injury: Clinical Evidence of N-Acetyl Cysteine Protective Effects
por: Ntamo, Yonela, et al.
Publicado: (2021)

Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

Oxidative stress mediated hepatotoxicity induced by ZNP and modulatory role of fruit extract on male Wistar rat
por: Singh, Neelu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7a88fsbbs3ptearhu0kvc4agjp