Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma

[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is a potent immunosuppressive enzyme that inhibits the antitumor immune response through both tryptophan metabolism and non-enzymatic functions. To date, most IDO1-targeted approaches have focused on inhibiting tryptophan metabolism. However, th...

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Autores principales: Bollu, Lakshmi R., Bommi, Prashant V., Monsen, Paige J., Zhai, Lijie, Lauing, Kristen L., Bell, April, Kim, Miri, Ladomersky, Erik, Yang, Xinyu, Platanias, Leonidas C., Matei, Daniela E., Bonini, Marcelo G., Munshi, Hidayatullah G., Hashizume, Rintaro, Wu, Jennifer D., Zhang, Bin, James, Charles David, Chen, Peiwen, Kocherginsky, Masha, Horbinski, Craig, Cameron, Michael D., Grigorescu, Arabela A., Yamini, Bakhtiar, Lukas, Rimas V., Schiltz, Gary E., Wainwright, Derek A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743093/
https://www.ncbi.nlm.nih.gov/pubmed/36410047
http://dx.doi.org/10.1021/acs.jmedchem.2c00771

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