Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication

Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical...

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Autores principales: Mekeirele, Michaël, Verheyen, Silke, Van Lancker, Ruth, Wuyts, Stephanie, Balthazar, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743138/
https://www.ncbi.nlm.nih.gov/pubmed/36518360
http://dx.doi.org/10.1159/000526323
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author Mekeirele, Michaël
Verheyen, Silke
Van Lancker, Ruth
Wuyts, Stephanie
Balthazar, Tim
author_facet Mekeirele, Michaël
Verheyen, Silke
Van Lancker, Ruth
Wuyts, Stephanie
Balthazar, Tim
author_sort Mekeirele, Michaël
collection PubMed
description Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications.
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spelling pubmed-97431382022-12-13 Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication Mekeirele, Michaël Verheyen, Silke Van Lancker, Ruth Wuyts, Stephanie Balthazar, Tim Case Rep Nephrol Dial Single Case Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepam intoxication. This technique proved to be effective in eliminating bromazepam in a patient with CHILD-C cirrhosis. We conclude that hemadsorption is a viable option to reduce length of ICU stay or intubation in slow metabolizers without contraindications. S. Karger AG 2022-09-26 /pmc/articles/PMC9743138/ /pubmed/36518360 http://dx.doi.org/10.1159/000526323 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Mekeirele, Michaël
Verheyen, Silke
Van Lancker, Ruth
Wuyts, Stephanie
Balthazar, Tim
Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title_full Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title_fullStr Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title_full_unstemmed Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title_short Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication
title_sort hemadsorption: a new therapeutic option for selected cases of bromazepam intoxication
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743138/
https://www.ncbi.nlm.nih.gov/pubmed/36518360
http://dx.doi.org/10.1159/000526323
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AT wuytsstephanie hemadsorptionanewtherapeuticoptionforselectedcasesofbromazepamintoxication
AT balthazartim hemadsorptionanewtherapeuticoptionforselectedcasesofbromazepamintoxication

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