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A perspective on Drosophila genetics and its insight into human neurodegenerative disease
Drosophila has been long appreciated as a classic genetic system for its ability to define gene function in vivo. Within the last several decades, the fly has also emerged as a premiere system for modeling and defining mechanisms of human disease by expressing dominant human disease genes and analyz...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743296/ https://www.ncbi.nlm.nih.gov/pubmed/36518845 http://dx.doi.org/10.3389/fmolb.2022.1060796 |
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author | Bonini, Nancy M. |
author_facet | Bonini, Nancy M. |
author_sort | Bonini, Nancy M. |
collection | PubMed |
description | Drosophila has been long appreciated as a classic genetic system for its ability to define gene function in vivo. Within the last several decades, the fly has also emerged as a premiere system for modeling and defining mechanisms of human disease by expressing dominant human disease genes and analyzing the effects. Here I discuss key aspects of this latter approach that first intrigued me to focus my laboratory research on this idea. Differences between the loss-of-function vs. the gain-of-function approach are raised—and the insight of these approaches for appreciating mechanisms that contribute to human neurodegenerative disease. The application of modifier genetics, which is a prominent goal of models of human disease, has implications for how specific genes or pathways intersect with the dominant disease-associated mechanisms. Models of human disease will continue to reveal unanticipated insight into fundamental cellular processes—insight that might be harder to glean from classical genetic methodologies vs modifier genetics of disease. |
format | Online Article Text |
id | pubmed-9743296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97432962022-12-13 A perspective on Drosophila genetics and its insight into human neurodegenerative disease Bonini, Nancy M. Front Mol Biosci Molecular Biosciences Drosophila has been long appreciated as a classic genetic system for its ability to define gene function in vivo. Within the last several decades, the fly has also emerged as a premiere system for modeling and defining mechanisms of human disease by expressing dominant human disease genes and analyzing the effects. Here I discuss key aspects of this latter approach that first intrigued me to focus my laboratory research on this idea. Differences between the loss-of-function vs. the gain-of-function approach are raised—and the insight of these approaches for appreciating mechanisms that contribute to human neurodegenerative disease. The application of modifier genetics, which is a prominent goal of models of human disease, has implications for how specific genes or pathways intersect with the dominant disease-associated mechanisms. Models of human disease will continue to reveal unanticipated insight into fundamental cellular processes—insight that might be harder to glean from classical genetic methodologies vs modifier genetics of disease. Frontiers Media S.A. 2022-11-28 /pmc/articles/PMC9743296/ /pubmed/36518845 http://dx.doi.org/10.3389/fmolb.2022.1060796 Text en Copyright © 2022 Bonini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Bonini, Nancy M. A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title | A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title_full | A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title_fullStr | A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title_full_unstemmed | A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title_short | A perspective on Drosophila genetics and its insight into human neurodegenerative disease |
title_sort | perspective on drosophila genetics and its insight into human neurodegenerative disease |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743296/ https://www.ncbi.nlm.nih.gov/pubmed/36518845 http://dx.doi.org/10.3389/fmolb.2022.1060796 |
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