Cargando…

Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells

BACKGROUND: Specific immune response is a hallmark of cancer immunotherapy and shared tumor-associated antigens (TAAs) are important targets. Recent advances using combined cellular therapy against multiple TAAs renewed the interest in this class of antigens. Our study aims to determine the role of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thelen, Martin, Keller, Diandra, Lehmann, Jonas, Wennhold, Kerstin, Weitz, Hendrik, Bauer, Eugen, Gathof, Birgit, Brüggemann, Monika, Kotrova, Michaela, Quaas, Alexander, Mallmann, Christoph, Chon, Seung-Hun, Hillmer, Axel M, Bruns, Christiane, von Bergwelt-Baildon, Michael, Garcia-Marquez, Maria Alejandra, Schlößer, Hans Anton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743382/ https://www.ncbi.nlm.nih.gov/pubmed/36600602 http://dx.doi.org/10.1136/jitc-2022-005200

Ejemplares similares

Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma
por: Lechner, Axel, et al.
Publicado: (2019)

CD40-activated B cells induce anti-tumor immunity in vivo
por: Wennhold, Kerstin, et al.
Publicado: (2016)

Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma
por: Leuchte, Katharina, et al.
Publicado: (2020)

Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma
por: Garcia-Marquez, Maria A., et al.
Publicado: (2021)

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma
por: Lechner, Axel, et al.
Publicado: (2017)

Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy
por: Thelen, Martin, et al.
Publicado: (2021)

Successful Esophago-Enterostomy
Publicado: (1898)

Cell type‐specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics
por: Krämer, Max, et al.
Publicado: (2020)

Distribution of tumor-infiltrating-T-lymphocytes and possible tumor-escape mechanisms avoiding immune cell attack in locally advanced adenocarcinomas of the esophagus
por: Schoemmel, M., et al.
Publicado: (2021)

Reply to: Letter to the Editor: More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis, by Marchegiani, Giovanni et al.
por: Hempel, Sebastian, et al.
Publicado: (2022)

Occurrence of Hepatocellular Carcinoma in a 40-Year-Old Male With MEN2A Syndrome
por: Kontoghiorghes, Christopher P, et al.
Publicado: (2021)

Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects
por: Szczesniak, Michal Marcin, et al.
Publicado: (2011)

Anti-angiogenic therapies for advanced esophago-gastric cancer
por: Fontana, Elisa, et al.
Publicado: (2014)

Cervical Esophago-Gastric Tubes for Patients with Malignant Ascites
por: Liang, Diana H., et al.
Publicado: (2016)

Iatrogenic Cerebral Air Embolism During Esophago-Gastroduodenoscopy
por: Betancourt-Torres, Manuel, et al.
Publicado: (2020)

Perspectives on the Management of Oligometastatic Disease in Esophago-Gastric Cancer
por: Goetze, Thorsten Oliver, et al.
Publicado: (2022)

Carcinosarcoma of the esophago-gastric junction—a case description
por: Włodarczyk, Janusz, et al.
Publicado: (2022)

Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma
por: Gebauer, Florian, et al.
Publicado: (2020)

Y Chromosome Loss Is a Frequent Event in Barrett’s Adenocarcinoma and Associated with Poor Outcome
por: Loeser, Heike, et al.
Publicado: (2020)

Immune Gene Rearrangements: Unique Signatures for Tracing Physiological Lymphocytes and Leukemic Cells
por: Kotrova, Michaela, et al.
Publicado: (2021)

PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis
por: Essakly, Ahlem, et al.
Publicado: (2019)

PHARYNGO-ILEO-COLO-ANASTOMOSIS WITH MICRO-VASCULAR BLOOD SUPPLY AUGMENTATION FOR ESOPHAGO-GASTRIC REPLACEMENT DUE TO ESOPHAGO-GASTRIC NECROSIS AFTER CAUSTIC INGESTION
por: BRAGHETTO, Italo, et al.
Publicado: (2018)

Emergency treatment of esophago-gastric lesion in caustic ingestion patients
por: Conforto, F, et al.
Publicado: (2004)

Isolated Crohn’s disease of the esophagus with esophago-mediastinal fistula formation
por: Wang, Wuping, et al.
Publicado: (2012)

The Prognostic Impact of Histology in Esophageal and Esophago-Gastric Junction Adenocarcinoma
por: Fiocca, Roberto, et al.
Publicado: (2021)

More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis
por: Hempel, Sebastian, et al.
Publicado: (2021)

Factors That Influence Conversion to Resectability and Survival After Resection of Metastases in RAS WT Metastatic Colorectal Cancer (mCRC): Analysis of FIRE-3- AIOKRK0306
por: Modest, Dominik Paul, et al.
Publicado: (2020)

The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
por: Shimabukuro-Vornhagen, Alexander, et al.
Publicado: (2012)

Systemic Immune Response in Murine Bilateral Pheochromocytoma Model During Immunotherapy Based on a Combination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibodies (MBTA Therapy)
por: Uher, Ondrej, et al.
Publicado: (2021)

Anorectal motility in patients with achalasia of the esophagus: recognition of an esophago-rectal syndrome
por: Shafik, Ahmed
Publicado: (2003)

Laparoscopic esophago-gastrostomy in the management of achalasia cardia – A case report
por: C S, Nagamallesh, et al.
Publicado: (2020)

Direct and indirect CT imaging features of esophago-airway fistula in adults
por: Little, Brent P., et al.
Publicado: (2020)

Amplatzer occluders for refractory esophago-respiratory fistulas: a case series
por: Belle, Arthur, et al.
Publicado: (2021)

Evaluation of postoperative surveillance strategies for esophago-gastric cancers in the UK and Ireland
por: Chidambaram, Swathikan, et al.
Publicado: (2021)

Management of Esophago-Gastric Junction Carcinoma: A Narrative Multidisciplinary Review
por: Tondolo, Vincenzo, et al.
Publicado: (2023)

Esophago-Pleural Fistula Complicating a Laparoscopic Adjustable Gastric Band
por: Adekunle, Ayooluwatomiwa D., et al.
Publicado: (2022)

Characterization of tumor-associated B-cell subsets in patients with colorectal cancer
por: Shimabukuro-Vornhagen, Alexander, et al.
Publicado: (2014)

Extension of resection after positive intraoperative pathology during surgery for gastric and gastroesophageal junction adenocarcinoma: a retrospective cohort study
por: Plum, Patrick S., et al.
Publicado: (2023)

Two decades of gastric and gastroesophageal junction cancer surgery
por: Plum, Patrick S., et al.
Publicado: (2023)

Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages
por: Murgaski, Aleksandar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rfq29uvp1t6pvoncvd13kr9agr