Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

INTRODUCTION: Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. D...

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Detalles Bibliográficos
Autores principales: Hla, Thel Khin, Osowicki, Joshua, Salman, Sam, Batty, Kevin T, Marsh, Julie A, Kado, Joseph, Barr, Renae, Enkel, Stephanie L, Snelling, Thomas L, McCarthy, James, Steer, Andrew C, Carapetis, Jonathan, Manning, Laurens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Infectious Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743388/
https://www.ncbi.nlm.nih.gov/pubmed/36600395
http://dx.doi.org/10.1136/bmjopen-2022-064022

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