Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data

BACKGROUND: Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway. RAF-fusions are the most common genetic alterations identified in JPAs, with the prototyp...

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Detalles Bibliográficos
Autores principales: Zwaig, Melissa, Baguette, Audrey, Hu, Bo, Johnston, Michael, Lakkis, Hussein, Nakada, Emily M., Faury, Damien, Juretic, Nikoleta, Ellezam, Benjamin, Weil, Alexandre G., Karamchandani, Jason, Majewski, Jacek, Blanchette, Mathieu, Taylor, Michael D., Gallo, Marco, Kleinman, Claudia L., Jabado, Nada, Ragoussis, Jiannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743522/
https://www.ncbi.nlm.nih.gov/pubmed/36503484
http://dx.doi.org/10.1186/s12885-022-10359-z

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