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Incidence and severity of immune-related hepatitis after dual checkpoint therapy is linked to younger age independent of herpes virus immunity

BACKGROUND AND AIMS: Dual immune checkpoint blockade (ICB) therapy can result in immune-related-adverse events (irAE) such as ICB-hepatitis. An expansion of effector-memory (TEM) CD4 T cells associated with antiviral immunity against herpesviridae was implicated in ICB-hepatitis. Notably, these memo...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhen, Rafei-Shamsabadi, David, Lehr, Saskia, Buettner, Nico, Diehl, Rebecca, Huzly, Daniela, Pinato, David J, Thimme, Robert, Meiss, Frank, Bengsch, Bertram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743538/ https://www.ncbi.nlm.nih.gov/pubmed/36503532 http://dx.doi.org/10.1186/s12967-022-03755-3

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