Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis

BACKGROUND: Takayasu arteritis (TAK) is characterized by pro-inflammatory M1 macrophage infiltration and increased interferon (IFN)-γ expression in vascular lesions. IFN-γ is a key cytokine involved in M1 polarization. Macrophage polarization is accompanied by metabolic changes. However, the metabol...

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Detalles Bibliográficos
Autores principales: Chen, Rongyi, Wang, Jinghua, Dai, Xiaojuan, Wu, Sifan, Huang, Qingrong, Jiang, Lindi, Kong, Xiufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743547/
https://www.ncbi.nlm.nih.gov/pubmed/36510278
http://dx.doi.org/10.1186/s13075-022-02960-1

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