Cargando…

Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

BACKGROUND: Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point inhibitors have shown activity in programmed death-ligand 1 (PD-L1) – positive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Voutilainen, S., Heikkilä, P., Bartkova, J., Nevanlinna, H., Blomqvist, C., Bartek, J., Mattson, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743555/ https://www.ncbi.nlm.nih.gov/pubmed/36503417 http://dx.doi.org/10.1186/s12885-022-10408-7

Ejemplares similares

Valproic Acid Regulates HR and Cell Cycle Through MUS81-pRPA2 Pathway in Response to Hydroxyurea
por: Su, Benyu, et al.
Publicado: (2021)

Genome Instability and γH2AX
por: Georgoulis, Anastasios, et al.
Publicado: (2017)

RPA instabilities in finite nuclei at low density
por: Jacquot, B, et al.
Publicado: (1996)

MiR-34a Expression Has an Effect for Lower Risk of Metastasis and Associates with Expression Patterns Predicting Clinical Outcome in Breast Cancer
por: Peurala, Hanna, et al.
Publicado: (2011)

The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets
por: Guzmán Prieto, Ana M., et al.
Publicado: (2015)

Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene
por: Sharma, Richa, et al.
Publicado: (2023)

Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number
por: Ni, Songwei, et al.
Publicado: (2021)

Observation of an isoscalar meson AX(1565) in annihilation of the $\overline{p}p$-atom from P states
por: May, B, et al.
Publicado: (1989)

Protective efficacy of attenuated Salmonella Typhimurium strain expressing BLS, Omp19, PrpA, or SOD of Brucella abortus in goats
por: Leya, Mwense, et al.
Publicado: (2021)

Study of the reaction $^{76} Br (n _{th}, p) ^{76}Se$
por: Andersson, G L, et al.
Publicado: (1978)

MC-PRPA-HLFIA Cascade Detection System for Point-of-Care Testing Pan-Drug-Resistant Genes in Urinary Tract Infection Samples
por: Tao, Jin, et al.
Publicado: (2023)

Nuclear Modification Factor RpA of b jets in pPb collisions
por: CMS Collaboration
Publicado: (2014)

Microscopy analysis of the smallest subunit of the RPA complex, Rfa3p, prompts consideration of how RPA subunits gather at single-stranded DNA sites
por: Ramonatxo, Agnès, et al.
Publicado: (2021)

Histopathological features of breast tumours in BRCA1, BRCA2 and mutation-negative breast cancer families
por: Eerola, Hannaleena, et al.
Publicado: (2005)

Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families
por: Eerola, Hannaleena, et al.
Publicado: (2005)

Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells
por: Xia, Li, et al.
Publicado: (2017)

Memorandum: ISRC-76-36 (P95)
por: CERN. Geneva. Intersecting Storage-Rings Committee
Publicado: (1977)

P16/Ki-67 Immunostaining is Useful in Stratification of Atypical Metaplastic Epithelium of the Cervix
por: Walts, Ann E., et al.
Publicado: (2008)

Neurogranin Regulates Metaplasticity
por: Zhong, Ling, et al.
Publicado: (2020)

Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma
por: Lien, Huang-Chun, et al.
Publicado: (2023)

Breed-related expression patterns of Ki67, γH2AX, and p21 during ageing in the canine liver
por: Hardwick, Laura J. A., et al.
Publicado: (2020)

HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation
por: Quan, Jinhua, et al.
Publicado: (2014)

Using Microsoft Dynamics AX: the new dynamics 'AX 7'
por: Luszczak, Andreas
Publicado: (2016)

Thiol redox switches regulate the oligomeric state of cyanobacterial Rre1, RpaA and RpaB response regulators
por: Ibrahim, Iskander M., et al.
Publicado: (2022)

Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells
por: Atsumi, Yuko, et al.
Publicado: (2011)

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis
por: Shimada, Midori, et al.
Publicado: (2016)

Renormalized RPA at finite temperature
por: Avdeenkov, A V, et al.
Publicado: (1995)

Metaplastic carcinoma of the breast: an immunohistochemical study
por: Altaf, Fadwa J, et al.
Publicado: (2014)

Mechanochemical regulations of RPA's binding to ssDNA
por: Chen, Jin, et al.
Publicado: (2015)

Microsoft Dynamics AX implementation guide: your all-in-one guide to exploring and implementing Microsoft Dynamics AX
por: Kasat, Yogesh, et al.
Publicado: (2015)

Memorandum: CERN-SPSC-74-76/SPSC-P-76 (Neutron elastic scattering at very small angles)
por: CERN. Geneva. SPS Experiments Committee
Publicado: (1976)

The metaplastic mosaic of Barrett’s oesophagus
por: Biswas, Sujata, et al.
Publicado: (2018)

Synaptic Plasticity, Metaplasticity and Depression
por: Vose, Linnea R., et al.
Publicado: (2017)

The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability
por: Yoshioka, Ken-ichi, et al.
Publicado: (2012)

Performance of the AX-PET demonstrator
por: Beltrame, P, et al.
Publicado: (2011)

High throughput evaluation of gamma-H2AX
por: Avondoglio, Dane, et al.
Publicado: (2009)

The spindle gets the Axs
por: LeBrasseur, Nicole
Publicado: (2003)

Metaplastic Cdx2-depleted cells can be very disruptive neighbors
por: Lourenço, Filipe C., et al.
Publicado: (2018)

Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells
por: Li, Yuhuan, et al.
Publicado: (2020)

Vaccination of goats with a combination Salmonella vector expressing four Brucella antigens (BLS, PrpA, Omp19, and SOD) confers protection against Brucella abortus infection
por: Leya, Mwense, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fioigi2ossf859375mi39t2rro