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Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis

OBJECTIVES: Peri-implantitis was an inflammatory progress on the tissue around the implant. The Osteoprotegerin G1181C (rs2073618) polymorphism was reported to be related to the increased risk of the peri-implantitis, whereas another found no relationship. The present study was conducted to research...

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Autores principales: Xu, Min, Zhang, Churen, Han, Ye, Yue, Zhaoguo, Shu, Chang, Hou, Jianxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743567/
https://www.ncbi.nlm.nih.gov/pubmed/36503538
http://dx.doi.org/10.1186/s12903-022-02657-6
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author Xu, Min
Zhang, Churen
Han, Ye
Yue, Zhaoguo
Shu, Chang
Hou, Jianxia
author_facet Xu, Min
Zhang, Churen
Han, Ye
Yue, Zhaoguo
Shu, Chang
Hou, Jianxia
author_sort Xu, Min
collection PubMed
description OBJECTIVES: Peri-implantitis was an inflammatory progress on the tissue around the implant. The Osteoprotegerin G1181C (rs2073618) polymorphism was reported to be related to the increased risk of the peri-implantitis, whereas another found no relationship. The present study was conducted to research the relationship between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility. MATERIALS AND METHODS: The meta-analysis was performed according to the Preferred Reporting Items for Systematic reviews. Electronic databases including PubMed, Web of science, Springer Link and Embase (updated to April 15, 2022) were retrieved. The cohort study, case-control study or cross-sectional study focusing on the Osteoprotegerin rs2073618 polymorphism and peri-implantitis were retrieved. The data included basic information of each study and the genotype and allele frequencies of the cases and controls. RESULTS: Three studies were finally included, including 160 cases and 271 controls. Allelic model, homozygote model, recessive model, dominant model, and heterozygous model were established to assess the relationship between OPG rs2073618 polymorphism and peri-implantitis susceptibility. The Osteoprotegerin rs2073618 polymorphism was significantly associated with peri-implantitis in Recessive model and Homozygote model. CONCLUSION: OPG rs2073618 polymorphism in Recessive model and Homozygote model was highly likely related to the risk of peri-implantitis. PROSPERO registration number: CRD42022320812 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-022-02657-6.
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spelling pubmed-97435672022-12-13 Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis Xu, Min Zhang, Churen Han, Ye Yue, Zhaoguo Shu, Chang Hou, Jianxia BMC Oral Health Research OBJECTIVES: Peri-implantitis was an inflammatory progress on the tissue around the implant. The Osteoprotegerin G1181C (rs2073618) polymorphism was reported to be related to the increased risk of the peri-implantitis, whereas another found no relationship. The present study was conducted to research the relationship between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility. MATERIALS AND METHODS: The meta-analysis was performed according to the Preferred Reporting Items for Systematic reviews. Electronic databases including PubMed, Web of science, Springer Link and Embase (updated to April 15, 2022) were retrieved. The cohort study, case-control study or cross-sectional study focusing on the Osteoprotegerin rs2073618 polymorphism and peri-implantitis were retrieved. The data included basic information of each study and the genotype and allele frequencies of the cases and controls. RESULTS: Three studies were finally included, including 160 cases and 271 controls. Allelic model, homozygote model, recessive model, dominant model, and heterozygous model were established to assess the relationship between OPG rs2073618 polymorphism and peri-implantitis susceptibility. The Osteoprotegerin rs2073618 polymorphism was significantly associated with peri-implantitis in Recessive model and Homozygote model. CONCLUSION: OPG rs2073618 polymorphism in Recessive model and Homozygote model was highly likely related to the risk of peri-implantitis. PROSPERO registration number: CRD42022320812 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-022-02657-6. BioMed Central 2022-12-12 /pmc/articles/PMC9743567/ /pubmed/36503538 http://dx.doi.org/10.1186/s12903-022-02657-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Xu, Min
Zhang, Churen
Han, Ye
Yue, Zhaoguo
Shu, Chang
Hou, Jianxia
Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title_full Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title_fullStr Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title_full_unstemmed Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title_short Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
title_sort association between osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743567/
https://www.ncbi.nlm.nih.gov/pubmed/36503538
http://dx.doi.org/10.1186/s12903-022-02657-6
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