Calcitriol increases MBNL1 expression and alleviates myotonic dystrophy phenotypes in HSA(LR) mouse models

BACKGROUND: Myotonic dystrophy type 1 (DM1), one of the most common forms of adult-onset muscular dystrophy, is caused by abnormally expanded CTG repeats in the 3′ untranslated region of the DMPK gene. The CUG repeats transcribed from the expanded CTG repeats sequestrate a splicing factor, MBNL1, ca...

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Detalles Bibliográficos
Autores principales: Huang, Kun, Wang, Dan-Dan, Hu, Wen-Bao, Zeng, Wei-Qian, Xu, Xia, Li, Qiu-Xiang, Bi, Fang-Fang, Yang, Huan, Qiu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743610/
https://www.ncbi.nlm.nih.gov/pubmed/36510245
http://dx.doi.org/10.1186/s12967-022-03806-9

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