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Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative regulator of AKT/mTOR signaling pathway. Mutations in PTEN are found in patients with autism, epilepsy, or macrocephaly. In mouse models, Pten loss results in neuronal hypertrophy, hyperexcitability, seizures, and ASD-like...

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Detalles Bibliográficos
Autores principales:	Tariq, Kamran, Cullen, Erin, Getz, Stephanie A., Conching, Andie K.S., Goyette, Andrew R., Prina, Mackenzi L., Wang, Wei, Li, Meijie, Weston, Matthew C., Luikart, Bryan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/ https://www.ncbi.nlm.nih.gov/pubmed/36323257 http://dx.doi.org/10.1016/j.celrep.2022.111574

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