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Molecular bases of morphologically diffused tumors across multiple cancer types

Gastric cancer has two distinct subtypes: the diffuse (DGC) and the intestinal (IGC) subtypes. Morphologically, the former each consists of numerous scattered tiny tumors while the latter each has one or a few solid biomasses. The former tends to be more aggressive and takes place in younger patient...

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Autores principales: Liu, Dingyun, Xing, Feiyang, Wang, Yueying, Xiao, Jun, An, Zheng, Xu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744092/
https://www.ncbi.nlm.nih.gov/pubmed/36523564
http://dx.doi.org/10.1093/nsr/nwac177
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author Liu, Dingyun
Xing, Feiyang
Wang, Yueying
Xiao, Jun
An, Zheng
Xu, Ying
author_facet Liu, Dingyun
Xing, Feiyang
Wang, Yueying
Xiao, Jun
An, Zheng
Xu, Ying
author_sort Liu, Dingyun
collection PubMed
description Gastric cancer has two distinct subtypes: the diffuse (DGC) and the intestinal (IGC) subtypes. Morphologically, the former each consists of numerous scattered tiny tumors while the latter each has one or a few solid biomasses. The former tends to be more aggressive and takes place in younger patients than the latter. While these have long been documented, little is known about the underlying causes. Our hypothesis is that the level of sialic acid (SA) accumulation on the cancer cell surfaces is a key reason for the observed differences. Our transcriptomic data-based analyses provide evidence that (i) DGCs tend to deploy more SAs on cancer cell surfaces than IGCs; (ii) this gives rise to considerably stronger cell–cell electrostatic repulsion in DGCs due to the negative charge that each SA carries; and (iii) such repulsion drives stronger cell protrusion and metastasis. Similar observations as well as our transcriptomic data-based predictions hold for multiple other cancer types, namely breast, lung, prostate plus liver and thyroid cancers, each known to have diffuse-like vs. non-diffused subtypes as well as more aggressive behaviors like DGCs vs. IGCs. Hence, we speculate that the discovery presented here applies not only to gastric cancer but multiple and even potentially all cancer types having diffuse-like and non-diffused subtypes.
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spelling pubmed-97440922022-12-14 Molecular bases of morphologically diffused tumors across multiple cancer types Liu, Dingyun Xing, Feiyang Wang, Yueying Xiao, Jun An, Zheng Xu, Ying Natl Sci Rev Perspective Gastric cancer has two distinct subtypes: the diffuse (DGC) and the intestinal (IGC) subtypes. Morphologically, the former each consists of numerous scattered tiny tumors while the latter each has one or a few solid biomasses. The former tends to be more aggressive and takes place in younger patients than the latter. While these have long been documented, little is known about the underlying causes. Our hypothesis is that the level of sialic acid (SA) accumulation on the cancer cell surfaces is a key reason for the observed differences. Our transcriptomic data-based analyses provide evidence that (i) DGCs tend to deploy more SAs on cancer cell surfaces than IGCs; (ii) this gives rise to considerably stronger cell–cell electrostatic repulsion in DGCs due to the negative charge that each SA carries; and (iii) such repulsion drives stronger cell protrusion and metastasis. Similar observations as well as our transcriptomic data-based predictions hold for multiple other cancer types, namely breast, lung, prostate plus liver and thyroid cancers, each known to have diffuse-like vs. non-diffused subtypes as well as more aggressive behaviors like DGCs vs. IGCs. Hence, we speculate that the discovery presented here applies not only to gastric cancer but multiple and even potentially all cancer types having diffuse-like and non-diffused subtypes. Oxford University Press 2022-08-26 /pmc/articles/PMC9744092/ /pubmed/36523564 http://dx.doi.org/10.1093/nsr/nwac177 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Liu, Dingyun
Xing, Feiyang
Wang, Yueying
Xiao, Jun
An, Zheng
Xu, Ying
Molecular bases of morphologically diffused tumors across multiple cancer types
title Molecular bases of morphologically diffused tumors across multiple cancer types
title_full Molecular bases of morphologically diffused tumors across multiple cancer types
title_fullStr Molecular bases of morphologically diffused tumors across multiple cancer types
title_full_unstemmed Molecular bases of morphologically diffused tumors across multiple cancer types
title_short Molecular bases of morphologically diffused tumors across multiple cancer types
title_sort molecular bases of morphologically diffused tumors across multiple cancer types
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744092/
https://www.ncbi.nlm.nih.gov/pubmed/36523564
http://dx.doi.org/10.1093/nsr/nwac177
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