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Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies
Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic autoimmune liver disease. Its characteristic is the destruction of intrahepatic bile ducts with portal inflammation and scarring. In the setting of cholestasis, there is a reduction in bile acid production and, consequently,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744100/ https://www.ncbi.nlm.nih.gov/pubmed/36523736 http://dx.doi.org/10.7759/cureus.31411 |
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author | Ahoussougbemey Mele, Ange Mahmood, Riaz Ogbuagu, Henry Fombi, Jason |
author_facet | Ahoussougbemey Mele, Ange Mahmood, Riaz Ogbuagu, Henry Fombi, Jason |
author_sort | Ahoussougbemey Mele, Ange |
collection | PubMed |
description | Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic autoimmune liver disease. Its characteristic is the destruction of intrahepatic bile ducts with portal inflammation and scarring. In the setting of cholestasis, there is a reduction in bile acid production and, consequently, decreased intestinal absorption of cholesterol. The result is the endogenous synthesis of cholesterol in the liver and the secretion of very low-density lipoprotein. Mixed hyperlipidemia can be challenging to manage, and the association with increased cardiovascular events remains unclear. |
format | Online Article Text |
id | pubmed-9744100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-97441002022-12-14 Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies Ahoussougbemey Mele, Ange Mahmood, Riaz Ogbuagu, Henry Fombi, Jason Cureus Internal Medicine Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic autoimmune liver disease. Its characteristic is the destruction of intrahepatic bile ducts with portal inflammation and scarring. In the setting of cholestasis, there is a reduction in bile acid production and, consequently, decreased intestinal absorption of cholesterol. The result is the endogenous synthesis of cholesterol in the liver and the secretion of very low-density lipoprotein. Mixed hyperlipidemia can be challenging to manage, and the association with increased cardiovascular events remains unclear. Cureus 2022-11-12 /pmc/articles/PMC9744100/ /pubmed/36523736 http://dx.doi.org/10.7759/cureus.31411 Text en Copyright © 2022, Ahoussougbemey Mele et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Ahoussougbemey Mele, Ange Mahmood, Riaz Ogbuagu, Henry Fombi, Jason Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title | Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title_full | Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title_fullStr | Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title_full_unstemmed | Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title_short | Hyperlipidemia in the Setting of Primary Biliary Cholangitis: A Case Report and Review of Management Strategies |
title_sort | hyperlipidemia in the setting of primary biliary cholangitis: a case report and review of management strategies |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744100/ https://www.ncbi.nlm.nih.gov/pubmed/36523736 http://dx.doi.org/10.7759/cureus.31411 |
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